Abstract:

Objective  To investigate the efficacy of liraglutide and metformin on metabolic and endocrine parameters in polycystic ovary syndrome (PCOS) patients with type 2 diabetes mellitus (T2DM). Methods  A total of 62 PCOS patients with T2DM were randomly divided into two groups， and liraglutide (1.21.8  mg/d ) or metformin (0.5  g/d) were used for 12 weeks， respectively. Metabolic parameters and sexual hormones were evaluated before and after treatment. Results  After 12 weeks’  treatment， the levels of FPG， 2 hPG， HbA1c， BMI and HOMAIR  were significantly improved in both groups (P<0.05)， and the improvement in liraglutide group was superior than that in metformin group (P<0.05). After treatment， the levels of LH and T were significantly reduced in both groups (P<0.05)， however， there were no significant difference in sexual hormones in pretreatment and posttreatment(P>0.05). Conclusion  Liraglutide can improve hyperglycemia and insulin resistance in PCOS patients with T2DM， and can also be helpful in improving hyperandrogenism.

Key words: polycystic ovary syndrome；diabetes mellitus, type 2；metformin； liraglutide