Abstract: Objective To  investigate the effects of lymphocyte to monocyte ratio (LMR) on prognosis assessment of patients with nonHodgkin lymphoma (NHL). Methods Fiftysix patients were enrolled and classified into two groups according to the median value (2.17) of LMR. Multivariate analysis was used to evaluate the association of age， gender， international prognostic index (IPI)， and absolute value of cell subsets in peripheral blood with progress free survival (PFS) and overall survival (OS). Results The two year probabilities of PFS and OS were （55.7±7.7）%  and  （76.1±6.4）%， respectively. Multivariate analysis showed that LMR was associated with PFS (HR=0.167，95%CI=0.0560.503，P=0.001). Factors associated with OS included LMR (HR=0.120，95%CI=0.0140.998，P=0.050) and IPI (HR=4.763， 95%CI=0.98223.114，P=0.053). Conclusion Our results suggested that LMR is a simple  and feasible biomarker during preliminary diagnosis that could be used to predict clinical outcomes of patients with nonHodgkin lymphoma.