Abstract: Inflammatory bowel disease comprises ulcerative colitis and Crohn disease， both of which are characterized by a tendency of chronic or relapsing immune activation and inflammation within the gastrointestinal tract. Immunomodulating drugs， including azathioprine， methotrexate and cyclosporine etc. are most useful in managing steroids resistant or dependent patients to achieve steroidsfree remission.

Key words: inflammatory bowel diseases；immunosuppressive agents, azathioprine, methotrexate, cyclosporine