Abstract: ObjectiveTo investigate the correlation  between Helicobacter pylori (Hp) infection and gastric mucosal atrophy and intestinal metaplasia. MethodsThe study enrolled 114 cases with gastric mucosal atrophy and intestinal metaplasia. Hp infection was detected by rapid urease test and pathological result. ResultsThere were more female than male patients in gastric mucosa with intestinal metaplasia. The Hp positive rate in the patients with gastric mucosal atrophy and intestinal metaplasia was 44.74%， but there was no significant difference in Hp between the severity of intestinal epithelial metaplasia and intestinal epithelial atrophy (P>0.05). ConclusionHp infection was significantly associated with the occurrence and development of chronic atrophic gastritis and intestinal metaplasia. But the effect of Hp  infection severity of intestinal metaplasia and gastric mucosal atrophy was not obviovs，which may be more related to the age and coures of disease. It needs to anti Hp therapy and strengthen the monitoring and regular followup for  the patients  with chronic atrophic gastric mucosa and intestinal epithelial metaplasia， expecially in those with Hp infection positive.

Key words: gastritis, atrophic; , intestinal metaplasia;helicobacter pylori