Abstract: ObjectiveTo retrospectively analyze the ultrasonographic performance of 112 cases of diffuse malignant peritoneal mesothelioma， and the characteristics of ultrasound imaging. MethodsUltrasound imaging and clinical data of 112 cases of diffuse malignant peritoneal mesothelioma confirmed by pathology in our hospital were analyzed. ResultsIn 112 patients，including 45 males and 67 females， the proportion of male and female was 1∶1.5. The age of onset was 42-83 years old，mean age  （57.0±6.8)  years old. A total of 105 cases(93.8%) had asbestos exposure history. The success rate of puncture biopsy was 94.6%. Ultrasonic manifestations of diffuse malignant peritoneal mesothelioma showed diffuse thickening of the omentum in 112 cases(100%)， thickening of parietal peritoneum in 96 cases(85.7%)  and thickening of mesentery in 61 cases(54.5%)， and the thickness of uneven， irregular border. Blood flow spectrum of thickening omentum showed the resistance index increased. Abdominal lymph adenopathy was seen in 29  cases(25.9%)， bowel involvement in 57  cases(51.0%). Peritoneal biopsy puncture feeling was hard. The strips were full， bright appearance， transparent or gelatinous. There was medium to large ascites in abdominal cavity. ConclusionUltrasound examination and puncture biopsy guided by ultrasound for peritoneal thickening area  make the disease get a clear pathological diagnosis.

Key words: peritoneal neoplasms, mesothelioma, utrasonography