Abstract: Objective  To detect the joints of hemophilia patients with high frequency ultrasound, and to explore the correlation between ultrasound results and clinical factors. Methods  Nineteen cases of patients who were clearly diagnosed with  hemophilia were collected. Common data were investigated,  including the age of the first joint bleeding,  the number of hemorrhagic joints,  the frequency of joints bleeding and therapy method. Ultrasound was applied to detect the patients' shoulders,  elbows,  hips,  knees and ankles and the joints were scored by the Hemophilia Early Arthropathy Detection with Ultrasound（HEADUS）   system.  The correlation analysis was conducted for  the clinical factors. Results  Nineteen male patients were diagnosed with hemophilia A,   with their ages ranging  from 5 to 50 and average age being  (24.53±14.82)  years. A total of  116 joints were examined,  72（62.07%）  of which were found to have lesions. Cartilage lesion,  bone erosion or osteophyte,  synovial hypertrophy,  synovial vascular hyperplasia and joint effusion were 88.89% (64/72),  66.67%(48/72),  58.33%(42/72),  47.22%(34/72) and 26.39%(19/72),  respectively. The results of kappa test were consistent among the operators. The age of the patients was positively correlated with the number of hemorrhagic joints and the HEADUS score（r=0.700, P=0.001；r=0.631, P=0.004）;  the frequency of joint bleeding was positively correlated with HEADUS score(r=0.335, P=0.000).There was no correlation between the age of joint hemorrhage at the first time and the number of hemorrhage joint and HEADUS score(r=0.115, P=0.640；r=0.108, P=0.660). Conclusion  Ultrasonography can be used to evaluate the joint of hemophiliacs. The ultrasonic score related to the clinical factors can be used as an objective index to evaluate hemophilia osteoarthropathy and  worths  generalizing.

Key words: ultrasonography, , Doppler, , color；hemophilia A；osteoarthritis