Abstract: Objective  The clinical features of 165 patients with narcolepsy diagnosed in the sleep medicine center of Shandong Provincial Hospital to improve clinical physicians' understanding of narcolepsy. Methods  To study the clinical data of 165 patients with narcolepsy who were diagnosed and treated in the sleep medicine center of our hospital from January 2015 to August 2018 were analyzed retrospectively. Results  In 165 cases of narcolepsy,  the number of man was 2.3 times higher than that of woman and patients with cataplexy accounted for 84.24%,  which were more than that of previous  studies. Most of the patients were from Shandong province,  and most were diagnosed in August,  February and March. Age of onset,  incidence rate of the syndrome pentad of narcolepsy and other clinical manifestations were basically  the same as those of  the previous studies.Conclusion  Narcolepsy is a relatively rare nervous system disease,  whose  onset is accompanied with  diverse clinical manifestations and unknown etiology. Early diagnosis,  treatment and management of patients should be strengthened to improve their  quality of life.

Key words: narcolepsy, symptoms and signs