Abstract: Objective  To  investigate the relationship between peripheral blood lymphocyte and monocyte ratio (LMR) and clinical features of patients with diffuse large Bcell lymphoma (DLBCL),  and to  judge the prognosis and predict  the  relapse.Methods  The clinical data of 126 DLBCL patients was retrospectively analyzed. Statistical methods were used to analyze the relationship between clinical features,  prognosis and relapse,  and to explore the value of predicting relapse.Results  Patients in the low LMR (<2.25) group were often accompanied by B symptoms,  high IPI score,  late clinical stage,  and elevated β2microglobulin levels (P<0.05). Totally 43 cases of  126 patients (37.7%) suffered relapse,  with a median relapse time of 12 (270) months. Multivariate analysis (OR=2.586,  P=0.028)  showed that low LMR was significantly associated with relapse at followup,  low LMR was more risky than high LMR,  and low LMR was related to shorter overall survival (OS) and diseasefree survival (DFS) (OS: P=0.015; PFS: P=0.006). Conclusion  This study suggests that when LMR is less than 2.25, it indicates poor prognosis. And during the followup,  a  lower LMR can be used as a marker to predict  relapse in patients with DLBCL.

Key words: lymphoma, B cell;lymphocytes;monocytes, relapse;prognosis