Abstract: Objective  To determine whether rs312691 polymorphism downstream of KCNJ2 confers susceptibility to thyrotoxic periodic paralysis (TPP). Methods  Pubmed,  Embase,  Wanfang Chinese Periodical Database and China National Knowledge Infrastructure were systematically searched for control study related rs312691 polymorphism to thyrotoxic periodic paralysis. A metaanalysis was conducted on the association between the rs312691 polymorphism and TPP. Results  A total of 7  comparison studies including 610 patients and 351 controls were considered in the metaanalysis. The metaanalysis showed a positive  association between TPP and allele C of the rs312691 polymorphism in all study subjects (OR=3.072，95%CI 2.5903.643，P＜0.001). Stratification by HardyWeinberg equilibrium of the control group also identified  significant positive association between this polymorphism and the susceptibility of TPP (OR=2.804，95%CI 2.3043.413,  P<0.001). Conclusion  This metaanalysis shows that the rs312691 polymorphism confers susceptibility to thyrotoxic periodic paralysis.

Key words: thyrotoxicosis, Graves disease；hypokalemic periodic paralysis；rs312691； KCNJ2