Abstract: Objective  To investigate the efficacy and safety of percutaneous transluminal septal myocardiam ablation (PTSMA) via a transradial approach in patients with hypertrophic obstructive cardiomyopathy (HOCM). Methods  The clinical data of 32 patients with HOCM who underwent PTSMA treatment via a transradial approach were retrospectively analyzed. Left ventricular outflow tract (LVOT) thickness,  left ventricular outflow tract gradient (LVOTG) and interventricular septal (IVS) thickness and other indicators were observed and compared by cardiac color Doppler ultrasonography before and six months after the surgery. The efficacy of PTSMA was evaluated,  and the occurrence of complications were observed simultaneously. Results  PTSMA were successfully performed for 32 patients. The postoperative LVOTG decreased  from (75.17±12.70)  mmHg to (32.42±7.62)  mmHg,  and the postoperative IVS thickness decreased from (26.87±4.35) mm to (17.83±3.27)  mm. The preoperative LVOT thickness increased from (6.45±2.34) mm to (11.23±3.28) mm.  Postoperative LVOTG,  LVOT width and IVS thickness were better than before surgery,  all with statistically significant differences(P<0.01). The clinical symptoms were remarkably improved. In 11 patients,   transient thirddegree atrioventricular block (AVB) occurred during operation. In two patients with postoperative delayed thirddegree AVB,  one patient received a dualchamber pacemaker. There were no complications such as radial artery occlusion,  pericardial tamponade,  hemorrhage or acute pulmonary embolism. No dead case was found.Conclusion  PTSMA is a feasible method for treating HOCM,  which can significantly decrease LVOTG and IVS thickness,  improve clinical symptoms,  and the transradial approach is relatively safe.

Key words: cardiomyopathy, , hypertrophic；percutaneous transluminal septal myocardiam ablation；radial artery