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Metaanalysis of clinical characteristics of novel coronavirus pneumonia

  

  1. a.Department of Nephrology;  b.Department of Respiratory Medicine,  Puai Hospital Affiliated to Tongji Medical College,  Huazhong University of Science and Technology,  Wuhan 430033,  China
  • Online:2020-04-20 Published:2020-04-16
  • Contact: Corresponding author: Li Yuanyuan, Email: 18207190110@163.com

Abstract: Objective  To explore the clinical features and prognosis of novel coronavirus pneumonia (NCP). Methods  PubMed,  WANFANG,  and CNKI were searched to collect clinic trials involving clinical characteristics of NCP from inception to February 20,  2020. Results  A total of 5 crosssectional studies involving 436 patients were included. The metaanalysis showed that  common clinical characteristics were fever(0.89,95%CI0.80, 0.97),  cough (0.68,95%CI0.51, 0.85),  lymphopenia  (0.60,95%CI0.43, 0.77),  increased Creactive protein (CRP)(0.85,95%CI0.80, 0.90),  normal procalcitonin (PCT)(0.76,95%CI0.54, 0.99)  and bilateral chest CT involvement(0.88,95%CI0.79, 0.97). The case fatality rate was 9%. Conclusion  NCP mainly involves middleaged and elderly people,  with similar main clinical features and high  case fatality rate. However,  further exploration of large sample studies is still needed due to the limitation of the quality of included studies.

Key words: COVID19, clinical characteristics