Abstract: Objective  To investigate the correlation between blood lipids and the degree of coronary atherosclerosis in patients with type 2 diabetes and coronary heart disease. Methods  According to the status of coronary angiography,  a total of 286 patients with type 2 diabetes were divided into two groups: type 2 diabetes with coronary artery stenosis <50%(Group A),  and type 2 diabetes with coronary artery stenosis≥50% (Group B). General information and biochemical indicators between two groups were compared. Results  There was significant difference between two groups in the course of diabetes,  hemoglobin A1c (HbA1c),  lowdensity lipoprotein cholesterol(LDLC),  highdensity lipoprotein cholesterol (HDLC), and LDLC/HDLC（P＜0.05). Logistic multivariate regression analysis showed that: LDLC/HDLC was an independent risk factor for coronary atherosclerosis in patients with type 2 diabetes. The ROC curve results showed that the optimal critical point of LDLC/HDLC was 2.53,  at this time the sensitivity was 77.6%  and the specificity was 82.3%.Conclusion  LDLC/HDLC is better than LDLC and HDLC in predicting coronary artery disease in patients with type 2 diabetes.

Key words: diabetes mellitus；type 2； coronary artery disease； cholesterol, LDL, cholesterol, HDL