Abstract:

Objective To explore the relationship between indoleamine 2, 3-dioxygenase (IDO) and CD4 +in peripheral blood in patients with ulcerative colitis(UC).Methods Seventy-two patients with UC from August 2014 to January 2019 were retrospectively analyzed, and they were used as the observation group and 72 controls in the physical examination center during the same period were recruited. Aim to compare IDO and CD4+ between groups at different times and analyze the correlation between the two in the observation group.Results Compared with control group, IDO of patients in observation group was higher, while CD4+ was lower (all P<0.05). In observation group, the expression of IDO at active period was better than that at remission period, while CD4+ in peripheral blood of patients was lower than that at remission period (all P<0.05); CD4+ in peripheral blood of moderate-to-severe patients was lower than that of mild patients, which of severe patients was lower than that of moderate patients (all P<0.05); IDO of moderate-to-severe patients was higher than that of mild patients, which of severe patients was higher than that of mild patients (all P<0.05). Pearson correlation analysis showed that IDO was negatively correlated with CD4+ in peripheral blood in UC patients (r=-0.801, P=0.000).Conclusion The serum IDO level of UC patients increased, and the peripheral blood CD4+ expression level decreased, and they were negatively correlated.

Key words: colitis, ulcerative, serum IDO level, CD4 antigens