Correlation between 25-(OH)D3 and degree of coronary artery stenosis in patients with coronary heart disease

doi:10.3969/j.issn.1004-583X.2021.11.004

Abstract

Abstract:

Objective To study the correlation between 25-(OH)D₃ and the degree of coronary artery stenosis in patients with coronary heart disease(CHD).Methods Totally 216 patients who underwent coronary angiography(CAG) were divided into control group (43 cases), mild stenosis group (73 cases), moderate stenosis group (53 cases), and severe stenosis group (47 cases) on the basis of the diagnostic criteria for CHD and the Gensini score. The key observations were 25-(OH)D₃, total cholesterol(TC), high density lipoprotein-cholesterol (HDL-C), low-density lipoprotein cholesterol(LDL-C), triglyceride(TG), creatinine(Cr) and other indicators. Results Among the four groups, the differences were statistical significance in 25-(OH)D₃, male, HDL-C, LDL-C, TC and TG (P<0.05). 25-(OH)D₃ was negatively correlated with Gensini score (r=-0.355, P<0.001). Multiple logistic regression showed that high 25-(OH)D₃ was protective against coronary stenosis (B=-0.084, P<0.001). Receiver operating characteristic(ROC) curve showed that 25-(OH)D₃ had strong predictive value for the occurrence of CHD and severe coronary stenosis. Area under curve(AUC) of the former and the latter was respectively 0.74(95%CI: 0.663-0.817) and 0.72 (95%CI: 0.636-0.804),respectively; the optimal cut-off value was 17.57 ng/ml and 11.42 ng/ml, the sensitivity was 74.4% and 63.8%, and the specificity was 72.3% and 74.6%.Conclusion 25-(OH)D₃ had negative correlation with the degree of coronary stenosis. Higher 25-(OH)D₃ had a certain protective effect on coronary stenosis. The diagnosis for severe stenosis is significantly higher than for mild and moderate.

Key words: coronary disease, coronary stenosis, vitamin D, coronary angiography

CLC Number:

R541.4

Zhao Weifeng, Ma Chunyu. Correlation between 25-(OH)D₃ and degree of coronary artery stenosis in patients with coronary heart disease[J]. Clinical Focus, 2021, 36(11): 981-985.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.11.004

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I11/981

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References 22

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组别	例数	男性 [例(%)]	年龄 (岁)		BMI (kg/m²)			吸烟 [例(%)]		饮酒 [例(%)]		高血压 [例(%)]			糖尿病 [例(%)]
对照组	43	16(37.2)	60.3±9.70		25.48±3.67			10(23.3)		8(18.6)		23(53.3)			8(18.6)
轻度狭窄	73	48(65.8)^*	60.15±9.58		24.73±3.40			33(45.2)^*		29(39.7)		41(56.2)			23(31.5)
中度狭窄	53	36(67.9)^*	60.68±9.61		25.04±3.31			23(43.4)^*		14(26.4)		36(67.9)			17(32.1)
重度狭窄	47	33(70.2)^*	60.59±12.30		26.14±4.49			24(51.1)^*		13(27.7)		27(57.4)			14(29.8)
统计值		χ²=13.713	F=0.040		F=1.459		χ²=8.146		χ²=6.426		χ²=2.567			χ²=2.745
P值		0.030	0.989		0.227		0.043		0.093		0.463			0.433
组数	例数	25-(OH)D₃ (ng/ml)		HDL-C (mmol/L)	Cr (μmol/L)	LDL-C (mmol/L)			TG (mmol/L)				TC (mmol/L)			尿素 (mmol/L)
对照组	43	19.58±5.76		1.19±0.17	65.35±16.28	2.58±0.63			1.81±1.06				3.01±0.55			4.56±1.22
轻度狭窄	73	15.68±6.87		1.06±0.19^*	70.74±18.67	2.47±0.65			2.28±0.95				3.02±0.46			5.19±1.31
中度狭窄	53	15.54±7.19		0.95±0.13^*△	75.86±22.57	3.16±0.15^*△			3.30±0.18^*△				3.90±0.72^*△			5.18±1.73
重度狭窄	47	11.71±5.76^*△▲		0.95±0.31^*△	84.20±66.03	3.70±0.79^*△▲			11.71±5.76^*△▲				4.75±0.70^*△▲			5.34±1.76
统计值		F=11.247		F=14.079	F=2.432	H=73.601			H=111.123				H=105.583			H=6.589
P值		<0.01		<0.01	0.066	<0.01			<0.01				<0.01			0.086

组别	例数	男性 [例(%)]	年龄 (岁)		BMI (kg/m²)			吸烟 [例(%)]		饮酒 [例(%)]		高血压 [例(%)]			糖尿病 [例(%)]
对照组	43	16(37.2)	60.3±9.70		25.48±3.67			10(23.3)		8(18.6)		23(53.3)			8(18.6)
轻度狭窄	73	48(65.8)^*	60.15±9.58		24.73±3.40			33(45.2)^*		29(39.7)		41(56.2)			23(31.5)
中度狭窄	53	36(67.9)^*	60.68±9.61		25.04±3.31			23(43.4)^*		14(26.4)		36(67.9)			17(32.1)
重度狭窄	47	33(70.2)^*	60.59±12.30		26.14±4.49			24(51.1)^*		13(27.7)		27(57.4)			14(29.8)
统计值		χ²=13.713	F=0.040		F=1.459		χ²=8.146		χ²=6.426		χ²=2.567			χ²=2.745
P值		0.030	0.989		0.227		0.043		0.093		0.463			0.433
组数	例数	25-(OH)D₃ (ng/ml)		HDL-C (mmol/L)	Cr (μmol/L)	LDL-C (mmol/L)			TG (mmol/L)				TC (mmol/L)			尿素 (mmol/L)
对照组	43	19.58±5.76		1.19±0.17	65.35±16.28	2.58±0.63			1.81±1.06				3.01±0.55			4.56±1.22
轻度狭窄	73	15.68±6.87		1.06±0.19^*	70.74±18.67	2.47±0.65			2.28±0.95				3.02±0.46			5.19±1.31
中度狭窄	53	15.54±7.19		0.95±0.13^*△	75.86±22.57	3.16±0.15^*△			3.30±0.18^*△				3.90±0.72^*△			5.18±1.73
重度狭窄	47	11.71±5.76^*△▲		0.95±0.31^*△	84.20±66.03	3.70±0.79^*△▲			11.71±5.76^*△▲				4.75±0.70^*△▲			5.34±1.76
统计值		F=11.247		F=14.079	F=2.432	H=73.601			H=111.123				H=105.583			H=6.589
P值		<0.01		<0.01	0.066	<0.01			<0.01				<0.01			0.086

项目	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
项目	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
HDL-C	-3.622	0.685	27.919	0.000	0.027	-4.966	-2.278
TC	2.095	0.227	85.451	0.000	8.125	1.651	2.540
25-(OH)D₃	-0.084	0.022	14.052	0.000	0.919	-0.128	-0.040
男性	0.701	0.296	5.589	0.018	2.016	1.282	1.200

项目	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
项目	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
HDL-C	-3.622	0.685	27.919	0.000	0.027	-4.966	-2.278
TC	2.095	0.227	85.451	0.000	8.125	1.651	2.540
25-(OH)D₃	-0.084	0.022	14.052	0.000	0.919	-0.128	-0.040
男性	0.701	0.296	5.589	0.018	2.016	1.282	1.200

Correlation between 25-(OH)D₃ and degree of coronary artery stenosis in patients with coronary heart disease

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