Correlation analysis between neutrophil percentage-to-albumin ratio and degree of coronary artery stenosis

doi:10.3969/j.issn.1004-583X.2022.01.004

Abstract

Abstract:

Objective To explore the relationship between neutrophil percentage-to-albumin ratio (NPAR) and the degree of coronary artery stenosis. Methods A total of 406 patients who underwent coronary angiography (CAG) in Jinzhou Central Hospital from November 2020 to July 2021 were selected. They were divided into the non-CHD group (84 cases) and the CHD group (322 cases) as the CAG result. Gensini score was used to evaluate the degree of coronary artery stenosis. The independent risk factors for coronary heart disease and the correlation between Gensini score and NPAR were evaluate by Multivariate Logistic regression analysis and Spearman correlation analysis, respectively. Receiver operating characteristic (ROC) curve was drawed to assess the predictive value of NPAR for coronary heart disease. Results The independent risk factors for coronary heart disease are age, gender, high-sensitivity C-reactive protein, NPAR. Gensini score was positively correlated with NPAR (r=0.364, P<0.01); the areas under curve of the ROC curve was 0.687(95%CI 0.632-0.741, P<0.05), and the cutoff value, sensitivity, specificity of NPAR were 1.6128,50.3%, and 85.7%, respectively. Conclusion NPAR is positively correlated with the coronary artery stenosis degree, which has certain predictive value for coronary heart disease.

Key words: coronary disease, coronary vessels, serum albumin, ROC curve

CLC Number:

R541.4

Chen Xi, Jiang Shan. Correlation analysis between neutrophil percentage-to-albumin ratio and degree of coronary artery stenosis[J]. Clinical Focus, 2022, 37(1): 26-29.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2022.01.004

https://huicui.hebmu.edu.cn/EN/Y2022/V37/I1/26

Figures/Tables 5

项目	冠心病组 (n=322)	非冠心病组 (n=84)	统计值	P值
年龄( $x -$ ±s,岁)	64.04±9.77	57.67±9.41	t=-5.268	0.000
男性[例(%)]	211(65.5)	42(50.0)	χ²=6.840	0.009
糖尿病史[例(%)]	87(27.0)	16(19.0)	χ²=2.236	0.135
高血压史[例(%)]	188(58.4)	42(50.0)	χ²=1.907	0.167
吸烟史[例(%)]	112(34.8)	20(23.8)	χ²=3.656	0.056
饮酒史[例(%)]	61(18.9)	11(13.1)	χ²=1.562	0.211
BMI( $x -$ ±s,kg/m²)	25.43±1.86	25.07±2.63	t=-1.841	0.066

项目	冠心病组 (n=322)	非冠心病组 (n=84)	统计值	P值
年龄( $x -$ ±s,岁)	64.04±9.77	57.67±9.41	t=-5.268	0.000
男性[例(%)]	211(65.5)	42(50.0)	χ²=6.840	0.009
糖尿病史[例(%)]	87(27.0)	16(19.0)	χ²=2.236	0.135
高血压史[例(%)]	188(58.4)	42(50.0)	χ²=1.907	0.167
吸烟史[例(%)]	112(34.8)	20(23.8)	χ²=3.656	0.056
饮酒史[例(%)]	61(18.9)	11(13.1)	χ²=1.562	0.211
BMI( $x -$ ±s,kg/m²)	25.43±1.86	25.07±2.63	t=-1.841	0.066

项目	冠心病组(n=322)	非冠心病组(n=84)	统计值	P值
中性粒细胞百分比(%)	67.44±11.35	62.03±7.80	t=-4.124	0.000
淋巴细胞计数(×10⁹/L)	1.86±0.82	1.91±0.57	t=-1.916	0.055
血清白蛋白(g/L)	41.62±4.75	43.62±3.50	t=-3.591	0.005
肌酐(μmol/L)	67.02±15.44	63.80±14.29	t=-1.634	0.102
尿素(mmol/L)	5.72±2.83	5.37±1.38	t=-0.958	0.338
尿酸 (μmol/L)	314.58±87.92	317.90±100.33	t=0.299	0.765
总胆固醇(mmol/L)	4.72±1.15	4.78±0.96	t=-0.682	0.495
甘油三酯(mmol/L)	2.40±8.99	1.68±1.00	t=-0.963	0.336
高密度脂蛋白胆固醇(mmol/L)	1.17±0.30	1.23±0.29	t=-1.818	0.069
低密度脂蛋白胆固醇(mmol/L)	3.09±1.05	3.07±0.84	t=-0.073	0.942
高敏C反应蛋白(mg/L)	9.97±29.52	2.49±3.44	t=-4.766	0.000
NPAR	1.65±0.38	1.43±0.21	t=-5.046	0.000

因素	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
因素	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
年龄	0.072	0.015	20.408	0.000	1.075	1.043	1.108
性别	1.116	0.295	14.266	0.000	3.052	1.710	5.445
高敏C反应蛋白	0.125	0.043	8.439	0.004	1.133	1.042	1.233
NPAR	1.542	0.473	10.624	0.001	4.674	1.849	11.813

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