Abstract:

Objective To investigate the occurrence and possible influencing factors of furazolidone-containing quadruple therapy for Helicobacter pylori (Hp). Methods A retrospective analysis was performed on the data of a case of severe adverse reactions during the eradication of H. pylori who visited the First Affiliated Hospital of Shanxi Medical University from January 2020 to December 2020. CNKI, Wanfang Data knowledge service platform and PubMed database were searched by using “H.pylori”, “adverse reactions”, “furazolidone”, “Helicobacter pylori” as keywords, the possible adverse reactions and countermeasures of furazolidone during the eradication of Hp were assessed. Results The results showed that furazolidone-containing quadruple therapy for Helicobacter pylori could induced to hepatic dysfunction and anaphylactic shock, and Intestinal bacterial infection might be a factor of this adverse reaction. Conclusion During the eradication of Hp, furazolidone can cause serious adverse reactions including disulfiram-like reactions, toxic neuropsychiatric symptoms, hypertensive crisis, hepatic dysfunction, and toxic epidermal necrolysis. Over-dosage of drugs, combined underlying diseases, intestinal microflora is all potential factors in inducing adverse reactions. The clinicians should standardize clinical clinical drug use as the latest instructions of furazolidone.

Key words: furazolidone, adverse reactions, Helicobacter pylori