Renal clear cell carcinoma complicated with multiple myeloma: A case report and literature review

doi:10.3969/j.issn.1004-583X.2024.10.010

Abstract

Abstract:

Objective To explore the differential diagnosis of kidney cancer with bone metastasis combined with multiple myeloma and to share experience. Methods A case of renal clear cell carcinoma combined with multiple myeloma admitted to the Third Hospital of Hebei Medical University was retrospectively analyzed, and the related literature was reviewed. Results The middle-aged male had the history of renal cancer with 3 years. The patient was treated for “back pain”, and pathological biopsy of vertebral mass after systematic examination revealed that the patient had kidney cancer with bone metastasis complicated with multiple myeloma. Conclusion Clinicians should improve the understanding of the coexistence of these two malignant tumors, especially when new osteolytic lesions are present in patients with renal cell carcinoma, a comprehensive examination is conducted to distinguish bone metastasis and multiple myeloma.

Key words: carcinoma, renal cell, multiple myeloma, multiplicity carcinoma

CLC Number:

R730.26

Tian Xin, Zhao Li, Liu Huijing. Renal clear cell carcinoma complicated with multiple myeloma: A case report and literature review[J]. Clinical Focus, 2024, 39(10): 925-928.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.10.010

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I10/925

Figures/Tables 2

Fig.1 Lumbar MRI showed L1, L2, and L4 vertebral bone destruction and local spinal cord compression, the posterior margin of L1 vertebral body local kyphosis. DWI showed irregular high signal mass at L1 and upper margin of the lumbar vertebra. T1: longitudinal relaxation time; T2: transverse relaxation time; T2FS: T2-weighted fat-suppressed images; DWI: diffusion weighted imaging; ADC: apparent diffusion coefficient image

Fig.2 Needle biopsy of lumbar HE staining and immunohistochemical staining(×100) a. Pathology visualized an alveolar and nest-like structure of clear cell carcinoma (red arrow), with clear cytoplasm and nucleus at varying sizes. A plasmacytoma merges clear cell carcinoma cells (black arrow), with round or irregular cell body and nucleus. b. Immunohistochemical expression of Pax-8; c. Immunohistochemical expression of CA-9; d. Immunohistochemical expression of CD38

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