Abstract: Objective  To explore the clinical value of diffusionweighted imaging (DWI) in the assessment of glioma grade combined with magnetic resonance spectroscopy(MRS).Methods  The clinical data of 103 patients with glioma who visited Xinhua Hospital affiliated to Dalian University from January 2017 to August 2020 were retrospectively analyzed. According to the World Health Organization (WHO) classification of central nervous system tumors,  the patients were divided into two groups: lowgrade glioma(LGG) group (54 cases) and highgrade glioma(HGG) group (49 cases). The results of the diffusion coefficient (ADC),  relative apparent diffusion coefficient (rADC),  choline (Cho),  Creatine (Cr) and Nethanol tianmendong (NAA) in each group were comparatively assessed. Results  The ADC value were in LGG and HGG group were (1.51±0.47)×10-3 mm2/s and (1.37±0.29)×10-3 mm2/s(P<0.01) respectively; The rADC value  in LGG and HGG group were (1.87±0.49)×10-3 mm2/s and (1.66±0.37)×10-3 mm2/s(P<0.01) respectively; the ratio of Cho/Cr in LGG and HGG group were 2.21±0.46 and 4.02±0.48(P<0.01) respectively; The ratio of Cho/NAA in LGG and HGG group were 2.19±0.41 and 4.21±0.58(P<0.01) respectively; the ratios of NAA/Cr in LGG and HGG group were 0.81±0.22 and 0.47±0.11(P<0.01) respectively. The results of receiver operating characteristic  (ROC) curve showed that the area under the curve of ADC,  rADC,  Cho/Cr,  Cho/NAA and NAA/Cr were 0.750, 0.842, 0.766, 0.801 and 0.751，respectively,  which were all statistically significant. Conclusion  DWI and MRS have high application value in preoperative assessment of glioma grade, which complement the deficiency of conventional MRI sequence and play a guiding role in the formulation of clinical doctors' diagnosis and treatment plan.

Key words: neoplasms, , neuroepithelial, magnetic resonance imaging, magnetic resonance spectroscopy, diagnosis