Study on brain functional connectivity in patients with liver cancer with depression

doi:10.3969/j.issn.1004-583X.2023.06.009

Abstract

Abstract:

Objective To explore the effect of resting-state functional magnetic resonance imaging (rs-fMRI) on functional connectivity(FC) in liver cancer(LC) patients with depression. Methods Twenty-one LC patients with depression (depression group) and 27 LC patients without depression (non depression group) were treated with 1.5T MR scanner, and rs-fMRI was obtained. The difference of FC was compared between groups, then, the correlation between functional imaging index and Hamilton Depression Scale (HAMD) score was analyzed.Resultss The patients with liver cancer and depression showed significantly weakened FC in the default mode network (the precuneus, the hippocampus and the parahippocampal gyrus, the inferior parietal lobule), the executive network (the cingulate gyrus, the medial frontal gyrus, the superior / middle / inferior frontal gyrus), the sensorimotor network (cerebellum), the salience network (the left insular lobe) and the thalamic node brain interval. The functional connection between the default mode network (inferior parietal lobule) and the sensorimotor network (the left cerebellum) was significantly enhanced in patients with liver cancer and depression.Conclusion LC patients with depression showed the functional connectivity abnormalities in multiple depression-related brain regions, which may be related to the neuropathological mechanism.

Key words: liver neoplasms, depression, functional magnetic resonance imaging, functional connectivity

CLC Number:

R735.7

Li Ya, Du Taoming, Qiu Shixiang, Chen Chao, Zhong Liming. Study on brain functional connectivity in patients with liver cancer with depression[J]. Clinical Focus, 2023, 38(6): 532-536.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2023.06.009

https://huicui.hebmu.edu.cn/EN/Y2023/V38/I6/532

Figures/Tables 3

References 22

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脑区	ROI英文缩写	MNI坐标
脑区	ROI英文缩写	X	Y	Z
左侧颞上回	STG.L	22	-60	-10
左侧岛叶	INS.L	-36	12	-10
右侧岛叶	INS.R	48	4	2
左侧颞中回	MTG.L	-54	-36	-10
右侧楔前叶	PCUN.R	14	-66	22
左侧楔前叶	PCUN.L	2	-56	44
右侧壳核	PUT.R	24	6	-6
右侧丘脑	THA.R	14	-26	-2
左侧丘脑	THA.L	-6	-22	-2
右侧额上回	SFG.R	22	62	10
左侧额中回	MFG.L	-40	26	22
右侧额下回	IFG.R	56	22	18
左侧顶下小叶	IPG.L	-42	-40	52
左侧额内侧回	FGmed.L	0	60	-20
右侧额内侧回	FGmed.R	2	56	-18
右侧前扣带回	ACC.R	6	34	-10
左侧前扣带回	ACC.L	-6	34	12
左侧小脑	Cerebellum.L	-44	-42	-36
右侧小脑	Cerebellum.R	44	-44	-42
右侧海马	PHG.R	32	-34	-4

脑区	ROI英文缩写	MNI坐标
脑区	ROI英文缩写	X	Y	Z
左侧颞上回	STG.L	22	-60	-10
左侧岛叶	INS.L	-36	12	-10
右侧岛叶	INS.R	48	4	2
左侧颞中回	MTG.L	-54	-36	-10
右侧楔前叶	PCUN.R	14	-66	22
左侧楔前叶	PCUN.L	2	-56	44
右侧壳核	PUT.R	24	6	-6
右侧丘脑	THA.R	14	-26	-2
左侧丘脑	THA.L	-6	-22	-2
右侧额上回	SFG.R	22	62	10
左侧额中回	MFG.L	-40	26	22
右侧额下回	IFG.R	56	22	18
左侧顶下小叶	IPG.L	-42	-40	52
左侧额内侧回	FGmed.L	0	60	-20
右侧额内侧回	FGmed.R	2	56	-18
右侧前扣带回	ACC.R	6	34	-10
左侧前扣带回	ACC.L	-6	34	12
左侧小脑	Cerebellum.L	-44	-42	-36
右侧小脑	Cerebellum.R	44	-44	-42
右侧海马	PHG.R	32	-34	-4

项目	肝癌抑郁组(=21)	肝癌非抑郁组(=27)	/χ²值	值
年龄(岁)	55.620±11.079	59.110±12.314	-0.013	0.990
性别(男/女)	15/6	20/7	0.042	0.883
教育年限(年)	4.380±3.640	4.560±4.362	-0.148	0.44^b
饮酒(无/有)	13/8	21/6	1.441	0.230
吸烟(无/有)	13/8	21/6	1.441	0.230
能否承担费用(否/能)	11/10	8/19	2.557	0.110
疾病知情(是/否)	16/5	18/9	0.519	0.471
治疗次数	1.950±3.278	1.950±2.394	-1.031	0.308

项目	肝癌抑郁组(=21)	肝癌非抑郁组(=27)	/χ²值	值
年龄(岁)	55.620±11.079	59.110±12.314	-0.013	0.990
性别(男/女)	15/6	20/7	0.042	0.883
教育年限(年)	4.380±3.640	4.560±4.362	-0.148	0.44^b
饮酒(无/有)	13/8	21/6	1.441	0.230
吸烟(无/有)	13/8	21/6	1.441	0.230
能否承担费用(否/能)	11/10	8/19	2.557	0.110
疾病知情(是/否)	16/5	18/9	0.519	0.471
治疗次数	1.950±3.278	1.950±2.394	-1.031	0.308