Abstract: Objective  To investigate the clinical effects of trazodone on mood and sleep disorders in patients with Parkinson’s disease (PD) and observe the adverse reactions during the treatment. Methods  There were 39 patients of PD with anxiety (anxiety group),  34 cases of PD with depression (depression group),  27 cases of PD with sleep disorder (sleep disorder group),  25 cases of PD combined with anxiety,  depression,  and sleep disorders (complicated group). All patients were treated with trazodone. The patients were evaluated for anxiety,  depression,  sleep quality  before and after  treatment. The clinical effects on different groups were evaluated and the adverse reactions of patients were recorded at the same time.Results  After treatment,  the scale scores of anxiety,  depression,  and sleep in the patients were significantly lower than before,  and the scores of each scale decreased with the treatment prolonged(P<0.05).Conclusion  Trazodone can improve the mood and sleep disorder of patients significantly.

Key words: trazodone, Parkinson disease, anxiety, depression, sleep disorders