Abstract: ObjectiveTo systematically compare the risk of peripherally inserted central catheters(PICCs) and centralvenous catheters(CVCs) related vein thrombosis. MethodsThe PubMed， the Cochrane Library， CNKI， CBM and Wan fang databases were searched to find literatures evaluating PICCs and CVCs related vein thrombosis. ResultsA total of 17 studies with 6 299 participants were finally included in the metaanalysis. The pooled odd risk for PICCs related vein thrombosis was 2.785（95%CI=1.7964.321，P<0.01）. The pooled odd risk for malignant tumor and intensive care were  3.049 （95%CI=1.9494.770，P<0.01）  and 3.954（95%CI=2.1817.168，P<0.01）， respectively. NNT=-30， 95%CI=-31.25     -27.78. There were no publication bias，and the outcome was stable by the sensitivity analysis. ConclusionPICCs increased the morbidity of vein thrombosis， especially for malignant tumor and intensive care， so PICCs related vein thrombosis needs more attention in clinic.

Key words: venous thrombosis；catheterization, central venous； metaanalysis