Abstract: ObjectiveTo explore the feasibility of the mobile phone APP service platform for carrying out the interactive management and followup of patients with weight loss  in order to provide the basis for clinical practice. MethodsA total of  30 men and 30 women were selected from the center for physical examination and healthy weight loss management， age from 26 to 64 years (average age of 46.2±10.6 years). The 60 participants were randomly divided into two groups.Each group was 30 participants and balanced  in the gender ratio.The participants in two groups  were all given a very low carbohydrate diet with exercise method for weight loss for three months， including the test group of mobile phone APP for interactive followup management control group with routine followup for nine months. The weight loss compliance and weight loss effect between groups were comparatively analyzed. After six months of weight loss intervention， the degree of weight loss rebound  was compared between the two groups. Results
Compared with the outpatient group， the mobile phone APP weight management mode greatly improved the compliance of the customers， and enhaned the customers′ self weight management ability; After three months of healthy weight loss，the two groups of subjects showed differenr improvement in， BMI， fatty liver， blood lipid， blood glucose， blood pressure， CAP and other indicators were improved in different degrees， while weight loss in the APP group was better than that in the outpatient group compared with the initial (P<0.05).  At six months after self management， the indicators of two groups had  certain degree of rebound， the degree of rebound in APP group was lower than that of outpatient group(P<0.05). ConclusionThe mobile phone APP in healthy weight loss interactive management is an effective means of health weight management， diet and exercise compliance can effectively improve the weight， the ability to prevent the rebound and self management， it is worthy of popularization and application.

Key words: overweight, health education, mobile , APP , interactive management