Abstract: Objective  To evaluate the value of endoscopic ultrasonography in minimally invasive treatment of lowgrade gastrointestinal neuroendocrine neoplasm. Methods  The endoscopic and pathological data of 130 cases of neuroendocrine tumors of the stomach in our hospital were analyzed retrospectively. All cases were examined and found the tumor body by gastroscopy and the diagnosis was confirmed by immunohistochemistry,  minimally invasive endoscopic treatment,  in which 59 cases were treated by endoscopic ultrasonography,  and 71 cases were removed by direct microscopy. Results  All 130 cases diagnozed by pathology G grade,  incoluded  G1  114 cases, G2  16 cases. The patients were divided into two groups according to the preoperative evaluation of endoscopic ulrasonography(EUS).The positive rate of vertical cutting edge in the group without EUS evaluation was higher than that in EUS group (P=0.03),  but there was no significant difference in horizental edge positive between two groups. Followup results showed that 23 cases of retreatment were all multiple cases. Conclusion  Endoscopic resection of lowgrade gastrointestinal neuroendocrine neoplasm is a safe and effective method to improve endoscopic resection rate,  and the prognosis is good.

Key words: gastrointestinal neoplasms, neuroendocrine tumors, endoscopy,digestive system, ultrasonography, Doppler, followup studies