Abstract: Objective  To investigate the influence factors of in stent restenosis(ISR )after 1 year of percutaneous coronary intervention (PCI) in patients with coronary heart disease(CHD). Methods  A total of 54 CHDpatients  who had restenosis one year after PCI were enrolled in the cardiovascular department of Lanzhou First People's Hospitalfrom January 2017 to May 2018. Another 30 patients without restenosis were selected as control group.The glycated hemoglobin (HbAlc), myoglobin (Myo), uric acid (UA), homocysteine (Hcy), total bilirubin (TBIL), γglutamyltranspeptidase (GGT), triacyl Glycerin (TG), total cholesterol (TC), highdensity lipoprotein cholesterol (HDLC), lowdensity lipoprotein cholesterol (LDLC), apolipoprotein A1 (APOA1), apolipoprotein B (APOB), lipid Protein a［Lp(a)］, a myocardial infarction thrombolysis risk (TIMI) score were estimated.Therisk factors for restenosis after 1 year of PCI were analyzed.Results  Compared with the no restenosis group, the UA and MYO in the restenosis group were significantly increased(P<0.05). The logistic regression analysis found that the increase of UA, TBIL and MYO were independent risk factors for restenosis in CHD patients after 1 year. APOA is a protective factor. Conclusion  The increase of UA, TBIL and MYO is an independent risk factor for restenosis after PCI in patients with coronary heart disease. The increase of APOA is the protective factor.

Key words: coronary disease；angioplasty, , balloon, , coronary；coronary restenosis