Abstract: Objective  To study the clinical and electrophysiological features in patients with impaired glucose regulation(IGR). Methods  Motor nerve conduciton velocity(MCV) and Sensory nerve conduciton velocity(NCV) were performed in 40 IGR patients (IGR group),  40 diabetes mellitus patients (T2DM group) and 30 controls (control group). The fasting blood glucose,  postprandial blood glucose,  glycosylated hemoglobin (HbA1c) and the blood lipid were analyzed.Results  Compared with the control group,  NCV of the tibial nerves in IGR group was significantly slower（P<0.05）. NCV in T2DM group of every nerve was significantly slower（P<0.05）,  and was significantly slower in the tibial nerves and peroneal nevers（P<0.01）. More severe abnormal never conduction was found in lower limbs than in upper limbs in IGR group and T2DM group. The abnormal degree was more severe in sensory nerve than in motor never（P<0.05）. Diabetic peripheral neuropathy is associated with FBG,  2 hPBG and HbA1c in patients with IGR. Conclusion  The most common clinical and electrophysiological manifestation of diabetic neuropathy is sensory disturbance,  which is more severe in lower limbs. Subclinical diabetic peripheral neuropathy in IGR patients can be detected by electrophysiological examination which is useful to verify the range and extent of the nerve lesion involved in the early stage of diabetic peripheral neuropathy.

Key words: diabetic neuropathies；impaired glucose regulation, neural conduction