Abstract: Objective  To systematically evaluated the efficacy and safety of mesenchyme stem cells for treatment of perianal Crohn's disease. MethodsThe Pubmed, Cochrane Library, CNKI, CBM and Wan fang databases were searched to find studies reporting efficacy and/or safety of mesenchyme stem   cells for the treatment of  perianal Crohn's disease. Results  According to the inclusion criteria, 5 studies  met the inclusion criteria,including 436 patients. Meta analysis results showed that the therapeutic effect of mesenchymal stem cells was higher than that of control group (RR=1.348, 95%CI=1.0571.719, P=0.016), and number needed to treat(NNT)=8.78 (95%CI=4.8348.21). The highdose group showed a tendency to reduce the efficacy of mesenchymal stem cells (RR=0.500, 95%CI=0.1281.953, P=0.319). The safety of  mesenchymal stem  cells was higher than that of control  group（RR=0.796，95%CI=0.4171.519, P=0.489). No publication bias were  found and the outcome was stable by the sensitivity analysis. Conclusion  Mesenchymal stem cells  for the treatment of perianal Crohn's disease can improve healing and do not increase the adverse events.

Key words: crohn , disease；mesenchyme stem cell, perianal fistula