Abstract: Objective  To systematically evaluate the effects of highfat and lowsugar diet on respiratory function in patients with mechanical ventilation of  chronic obstructive pulmonary disease(COPD). Methods  Chinese and English databases, such as  China national knowledge infrastructure (CNKI),  VIP database (VIP),  Wanfang database,  PubMed,  EMbase were searched.  Randomized controlled trials(RCTs)  in  Chinese and English on highfat and lowsugar diet and COPD mechanical ventilation published in  2019  were collected  from January to October. Two researchers independently screened the literature that met the inclusion and exclusion criteria,  summarized the opinions and extracted the data. The Cochrane bias risk assessment tool was used to evaluate the quality of the literature. Results  A total of 15 RCTs were collected,  including 1 146  patients. Metaanalysis showed the data of  highfat and lowsugar group were higher than those of control group in many aspects,  such as VE(MD=-1.4, Z=8.23, P＜0.01, 95%CI -1.74, -1.07),  VCO2  (MD=-42.61, Z=8.65, P＜0.01, 95%CI -52.26, -32.96),  VO2(MD=-30.16, Z=7.37, P＜0.01, 95%CI -38.18,-22.14),  RQ(MD=-0.08, Z=19.3, P＜0.01, 95%CI -0.08,-0.07),  PaCO2(MD=-1.13, Z=5.93, P＜0.01, 95%CI -1.5, -0.76),  PaO2(MD=1.24, Z=8.02, P＜0.01, 95%CI 0.94, 1.54). Conclusion  Highfat  and lowsugar diets can improve respiratory function in patients with COPD mechanical ventilation,  reduce the production of CO,  lower PaCO2,  raise PaO2,  and correct respiratory failure.

Key words: pulmonary disease, , chronic obstructive；diet, , highfat；diet, , carbohydraterestricted；respiration, , artificial；respiratory function tests