Abstract: Objective  To analyze the clinical features,  treatment and followup of 4 children with preexcitation cardiomyopathy,  to understand the prognosis of the disease and to explore the influencing factors of preexcitation cardiomyopathy. Methods  The clinical data of 4 children with preexcitation cardiomyopathy in our hospital were analyzed retrospectively,  and the literature were reviewed to understand the prognosis and influencing factors of the disease.Results  All the 4 children met the diagnostic criteria of preexcitation cardiomyopathy. Totally 3 cases of them underwent intracardiac electrophysiological examination and were found with accessory pathways,  then  radiofrequency ablation was performed. The preexcitation syndrome of case 1 and case 2 disappeared,  while case 3 still had such syndrome. Echocardiography showed that the left ventricle gradually retracted and its function was significantly improved.  The prognosis of the disease was favorable. Case 4 had not yet undergone radiofrequency ablation and was currently at followup. Conclusion  The radiofrequency ablation is the first choice for the treatment of preexcitation cardiomyopathy and the prognosis is favorable. Age at diagnosis,  preexcitation load (persistent or intermittent) and type of preexcitation (location and number of accessory pathways) are the influencing factors of preexcitation cardiomyopathy.

Key words: preexcitation syndromes, , catheter ablation, accessory pathway, , nonsynchronous