Relations between serum immunoglobulin, level of complement C3 or complement C4 and prognosis of hypertensive intracerebral hemorrhage patients

doi:10.3969/j.issn.1004-583X.2021.02.002

Abstract

Abstract:

Objective To explore the relations between serum immunoglobulin, changes in complement C3 and complement C4 and prognosis of hypertensive intracerebral hemorrhage(HICH) patients. Methods One hundred and fifty HICH patients admitted by the hospital were selected as study subjects, and the patients were divided into good prognosis group and poor prognosis group according to Modified Rankin Scale(mRS) scores of patients in one month after the onset of diseases, and healthy people with normal physical results during the same period were selected into normal control group. Glasgow Coma Scale (GCS) scores, NIH Stroke Scale (NIHSS) scores and hematoma volume were collected. IgG, IgA, IgM and C3 and C4 of serum samples were determined by immunoturbidimetry. Results GCS scores of poor prognosis group on the the 1st day were significantly lower than those of good prognosis group (P<0.05), and NIHSS score, hematoma volume and WBC of poor prognosis group were significantly higher than those of good prognosis group (P<0.05).The comparative difference in the level of IgG, IgM, complement C3 or complement C4 of humoral immunity of patients in poor prognosis group, good prognosis group and control group on the 1st day was statistically significant (P<0.05), and the level of IgG, IgM, complement C3 or complement C4 of poor prognosis group and good prognosis group was significantly lower than those of the control group (P<0.05), the level of IgG, IgA, IgM or complement C3 or complement C4 of poor prognosis group was significantly lower than those of good prognosis group (P<0.05). The serum level of IgG or IgM of both groups was minimized on the 3rd day. IgG, IgM, complement C3 or complement C4 of poor prognosis group for inter-group and identical time-point comparison on the 1st 3rd days were lower than those of good prognosis group (P<0.05), and the level of complement C3 or complement C4 of poor prognosis group on the 11th day were higher than those of good prognosis group (P<0.05). The inter-group interactions of IgG, complement C3 and complement C4 of patients at identical or different time points were statistically significant (P<0.05), and the comparison in IgM of patients in groups at different time points was statistically significant (P<0.05). The level of IgG, IgM, complement C3 or complement C4 were positively correlated with GCS scores (P<0.05). The level of IgG, IgM, C3 or C4 was negatively correlated with NIHSS scores, hematoma volume and WBC (P<0.05). Conclusion HICH patients are found to have suppressed humoral immune, serum immunoglobulin and level of complement C3 or complement C4 below than that of normal patients, and HICH patients with poor prognosis show suppressed humoral immunity or activation level higher than that of patients with good prognosis.

Key words: intracranial hemorrhage, hypertensive, immunity, humoral, immunoglobulins, complement C3, complement C4

CLC Number:

R743.34

Wu Liang, Liu Ming. Relations between serum immunoglobulin, level of complement C3 or complement C4 and prognosis of hypertensive intracerebral hemorrhage patients[J]. Clinical Focus, 2021, 36(2): 107-111.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.02.002

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I2/107

Figures/Tables 4

References 15

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组别	例数	收缩压(mmHg)	舒张压(mmHg)	GCS(分)	NIHSS(分)	血肿量(ml)	WBC(×10⁹/L)
预后不良组	53	182.61±18.75	105.86±13.41	10.71±3.59	17.55±4.28	32.13±7.88	18.23±4.02
预后良好组	97	176.86±17.84	101.86±12.9	13.97±3.93	8.63±2.25	19.86±6.39	12.83±3.24
t值		1.853	1.790	5.115	16.740	9.191	8.947
P值		0.066	0.075	0.000	0.000	0.000	0.000

组别	例数	收缩压(mmHg)	舒张压(mmHg)	GCS(分)	NIHSS(分)	血肿量(ml)	WBC(×10⁹/L)
预后不良组	53	182.61±18.75	105.86±13.41	10.71±3.59	17.55±4.28	32.13±7.88	18.23±4.02
预后良好组	97	176.86±17.84	101.86±12.9	13.97±3.93	8.63±2.25	19.86±6.39	12.83±3.24
t值		1.853	1.790	5.115	16.740	9.191	8.947
P值		0.066	0.075	0.000	0.000	0.000	0.000

组别	例数	IgG	IgA	IgM	C3	C4
预后不良组	53	11.14±3.02^*△	2.47±0.72	1.06±0.33^*△	0.87±0.23^*△	0.24±0.08^*△
预后良好组	97	12.12±3.48	2.40±0.83	1.20±0.37^*	0.98±0.30^*△	0.27±0.07^*△
对照组	30	13.76±3.01	2.49±0.65	1.36±0.43	1.32±0.40	0.31±0.05
F值		6.128	0.231	6.486	22.131	9.631
P值		0.003	0.794	0.002	0.000	0.000

组别	例数	IgG	IgA	IgM	C3	C4
预后不良组	53	11.14±3.02^*△	2.47±0.72	1.06±0.33^*△	0.87±0.23^*△	0.24±0.08^*△
预后良好组	97	12.12±3.48	2.40±0.83	1.20±0.37^*	0.98±0.30^*△	0.27±0.07^*△
对照组	30	13.76±3.01	2.49±0.65	1.36±0.43	1.32±0.40	0.31±0.05
F值		6.128	0.231	6.486	22.131	9.631
P值		0.003	0.794	0.002	0.000	0.000

组别	例数		IgG			IgA
组别	例数		第1 d	第3 d	第11 d	第1 d	第3 d	第11 d
预后不良组	53		11.14±3.02^△	9.23±2.18^△*	13.83±4.00^*#	2.47±0.72	2.13±0.63	2.57±0.73
预后良好组	97		12.12±3.48	11.58±3.00^*	13.23±4.61^#	2.40±0.83	2.27±0.70	2.40±0.97
组间			F=24.283 P<0.05			F=0.545 P>0.05
时点间			F=4.209 P<0.05			F=0.317 P>0.05
组间·时点间			F=3.604 P<0.05			F=0.545 P>0.05
组别	例数		IgM			C3
组别	例数		第1 d	第3 d	第11 d	第1 d	第3 d	第11 d
预后不良组	53		1.06±0.33^△	0.63±0.22^△*	1.03±0.27^△	0.87±0.23^△	1.93±0.60^△*	1.93±0.53^△*
预后良好组	97		1.20±0.37	0.79±0.30^*	1.15±0.31^#	0.98±0.30	1.23±0.32^*	1.24±0.35^*
组间			F=676.909 P<0.05			F=377.926 P<0.05
时点间			F=64.146 P<0.05			F=68.333 P<0.05
组间·时点间			F=159.695 P<0.05			F=138.816 P<0.05
组别		例数	C4
组别		例数	第1 d		第3 d		第11 d
预后不良组		53	0.24±0.08^△		0.51±0.13^△*		0.43±0.11^△*
预后良好组		97	0.27±0.07		0.38±0.11^*		0.33±0.10
组间			F=199.264 P<0.05
时点间			F=88.583 P<0.05
组间·时点间			F=53.881 P<0.05