Clinical Focus ›› 2021, Vol. 36 ›› Issue (7): 664-668.doi: 10.3969/j.issn.1004-583X.2021.07.019
Previous Articles Next Articles
Received:
2021-03-06
Online:
2021-07-20
Published:
2021-08-02
CLC Number:
Add to citation manager EndNote|Ris|BibTeX
URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.07.019
[1] | Gadiyar V, Patel G, Davra V. Immunological role of TAM receptors in the cancer microenvironment[J]. Int Rev Cell Mol Biol, 2020,357:57-79. |
[2] |
Pagani S, Bellan M, Mauro D, et al. New insights into the role of Tyro3, Axl, and Mer receptors in rheumatoid arthritis[J]. Dis Markers, 2020,2020:1614627.
doi: 10.1155/2020/1614627 pmid: 32051695 |
[3] |
Nagata K, Ohashi K, Nakano T, et al. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases[J]. J Biol Chem, 1996,271(47):30022-30027.
pmid: 8939948 |
[4] | Lew ED, Oh J, Burrola PG, et al. Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities[J]. Elife, 2014: 3. |
[5] |
Godowski PJ, Mark MR, Chen J, et al. Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3[J]. Cell, 1995,82(3):355-358.
pmid: 7634325 |
[6] |
Lemke G. Biology of the TAM receptors[J]. Cold Spring Harb Perspect Biol, 2013,5(11):a009076.
doi: 10.1101/cshperspect.a009076 URL |
[7] |
Rothlin CV, Carrera-Silva EA, Bosurgi L, et al. TAM receptor signaling in immune homeostasis[J]. Annu Rev Immunol, 2015,33:355-391.
doi: 10.1146/annurev-immunol-032414-112103 pmid: 25594431 |
[8] |
Lai C, Gore M, Lemke G. Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase[J]. Oncogene, 1994,9(9):2567-2578.
pmid: 8058320 |
[9] |
Pierce AM, Keating AK. TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system[J]. Brain Res, 2014,1542:206-220.
doi: 10.1016/j.brainres.2013.10.049 URL |
[10] |
Schneider C, King RM, Philipson L. Genes specifically expressed at growth arrest of mammalian cells[J]. Cell, 1988,54(6):787-793.
pmid: 3409319 |
[11] |
Manfioletti G, Brancolini C, Avanzi G, et al. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade[J]. Mol Cell Biol, 1993,13(8):4976-4985.
doi: 10.1128/mcb.13.8.4976-4985.1993 pmid: 8336730 |
[12] |
Shafit-Zagardo B, Gruber RC, DuBois JC. The role of TAM family receptors and ligands in the nervous system: From development to pathobiology[J]. Pharmacol Ther, 2018,188:97-117.
doi: 10.1016/j.pharmthera.2018.03.002 URL |
[13] |
Morioka S, Maueröder C, Ravichandran KS. Living on the edge: Efferocytosis at the interface of homeostasis and pathology[J]. Immunity, 2019,50(5):1149-1162.
doi: S1074-7613(19)30198-0 pmid: 31117011 |
[14] |
Burstyn-Cohen T, Maimon A. TAM receptors, phosphatidylserine, inflammation, and cancer[J]. Cell Commun Signal, 2019,17(1):156.
doi: 10.1186/s12964-019-0461-0 pmid: 31775787 |
[15] |
Rajotte I, Hasanbasic I, Blostein M. Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine[J]. Biochem Biophys Res Commun, 2008,376(1):70-73.
doi: 10.1016/j.bbrc.2008.08.083 URL |
[16] |
Zagórska A, Través PG, Lew ED, et al. Diversification of TAM receptor tyrosine kinase function[J]. Nat Immunol, 2014,15(10):920-928.
doi: 10.1038/ni.2986 pmid: 25194421 |
[17] |
Geng K, Kumar S, Kimani SG, et al. Requirement of gamma-carboxyglutamic acid modification and phosphatidylserine binding for the activation of Tyro3, Axl, and Mertk receptors by growth arrest-specific 6[J]. Front Immunol, 2017,8:1521.
doi: 10.3389/fimmu.2017.01521 pmid: 29176978 |
[18] |
Camenisch TD, Koller BH, Earp HS, et al. A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock[J]. J Immunol, 1999,162(6):3498-3503.
pmid: 10092806 |
[19] |
Rothlin CV, Ghosh S, Zuniga EI, et al. TAM receptors are pleiotropic inhibitors of the innate immune response[J]. Cell, 2007,131(6):1124-1136.
pmid: 18083102 |
[20] |
Lu Q, Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family[J]. Science, 2001,293(5528):306-311.
pmid: 11452127 |
[21] |
Zhu H, Sun X, Zhu L, et al. Different expression patterns and clinical significance of mAxl and sAxl in systemic lupus erythematosus[J]. Lupus, 2014,23(7):624-634.
doi: 10.1177/0961203314520839 pmid: 24474706 |
[22] |
Gheita TA, Bassyouni IH, Bassyouni RH. Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl in patients with systemic lupus erythematosus and Behçets disease[J]. J Clin Immunol, 2012,32(6):1279-1286.
doi: 10.1007/s10875-012-9743-7 pmid: 22833165 |
[23] |
Wu CS, Hu CY, Tsai HF, et al. Elevated serum level of growth arrest-specific protein 6 (Gas6) in systemic lupus erythematosus patients is associated with nephritis and cutaneous vasculitis[J]. Rheumatol Int, 2014,34(5):625-629.
doi: 10.1007/s00296-013-2882-1 URL |
[24] | Cohen PL, Shao WH. Gas6/TAM receptors in systemic lupus erythematosus[J]. Dis Markers, 2019,2019:7838195. |
[25] |
Qin B, Wang J, Ma N, et al. The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjögren's syndrome[J]. Joint Bone Spine, 2015,82(4):258-263.
doi: 10.1016/j.jbspin.2015.01.008 URL |
[26] |
Chen CH, Chen HC, Chang CC, et al. Growth arrest-specific 6 protein in patients with Sjögren syndrome: Determination of the plasma level and expression in the labial salivary gland[J]. PLoS One, 2015,10(10):e0139955.
doi: 10.1371/journal.pone.0139955 URL |
[27] |
Rothlin CV, Leighton JA, Ghosh S. Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer[J]. Inflamm Bowel Dis, 2014,20(8):1472-1480.
doi: 10.1097/MIB.0000000000000050 pmid: 24846720 |
[28] |
Qin J, Li L, Zhang D, et al. Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Behçet's disease[J]. Sci Rep, 2016,6:26662.
doi: 10.1038/srep26662 URL |
[29] | Bellan M, Pirisi M, Sainaghi PP. The Gas6/TAM system and multiple sclerosis[J]. Int J Mol Sci, 2016,17(11). |
[30] |
Zhou Y, Wang Y, Chen H, et al. Immuno-oncology: Are TAM receptors in glioblastoma friends or foes[J]. Cell Commun Signal, 2021,19(1):11.
doi: 10.1186/s12964-020-00694-8 URL |
[31] |
Linger RM, Keating AK, Earp HS, et al. Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors[J]. Expert Opin Ther Targets, 2010,14(10):1073-1090.
doi: 10.1517/14728222.2010.515980 URL |
[32] | Linger RM, Keating AK, Earp HS, et al. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer[J]. Adv Cancer Res, 2008,100:35-83. |
[33] |
Wu G, Ma Z, Cheng Y, et al. Targeting Gas6/TAM in cancer cells and tumor microenvironment[J]. Mol Cancer, 2018,17(1):20.
doi: 10.1186/s12943-018-0769-1 URL |
[34] |
Birge RB, Boeltz S, Kumar S, et al. Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer[J]. Cell Death Differ, 2016,23(6):962-978.
doi: 10.1038/cdd.2016.11 pmid: 26915293 |
[35] |
Graham DK, DeRyckere D, Davies KD, et al. The TAM family: Phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer[J]. Nat Rev Cancer, 2014,14(12):769-785.
doi: 10.1038/nrc3847 URL |
[36] |
Nguyen KQ, Tsou WI, Calarese DA, et al. Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity[J]. J Biol Chem, 2014,289(37):25737-25749.
doi: 10.1074/jbc.M114.570838 URL |
[37] |
Hutterer M, Knyazev P, Abate A, et al. Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme[J]. Clin Cancer Res, 2008,14(1):130-138.
doi: 10.1158/1078-0432.CCR-07-0862 pmid: 18172262 |
[38] |
Rea K, Pinciroli P, Sensi M, et al. Novel Axl-driven signaling pathway and molecular signature characterize high-grade ovarian cancer patients with poor clinical outcome[J]. Oncotarget, 2015,6(31):30859-30875.
doi: 10.18632/oncotarget.v6i31 URL |
[39] |
Myers KV, Amend SR, Pienta KJ. Targeting Tyro3, Axl and MerTK (TAM receptors): Implications for macrophages in the tumor microenvironment[J]. Mol Cancer, 2019,18(1):94.
doi: 10.1186/s12943-019-1022-2 URL |
[40] | Poon IK, Lucas CD, Rossi AG, et al. Apoptotic cell clearance: Basic biology and therapeutic potential[J]. Nat Rev Immunol, 2014,14(3):166-180. |
[41] |
Moller-Tank S, Maury W. Phosphatidylserine receptors: Enhancers of enveloped virus entry and infection[J]. Virology. 2014. 468-470:565-580.
doi: S0042-6822(14)00420-6 pmid: 25277499 |
[42] |
Vanlandschoot P, Leroux-Roels G. Viral apoptotic mimicry: An immune evasion strategy developed by the hepatitis B virus[J]. Trends Immunol, 2003,24(3):144-147.
pmid: 12615210 |
[43] |
Mercer J, Helenius A. Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells[J]. Science, 2008,320(5875):531-535.
doi: 10.1126/science.1155164 pmid: 18436786 |
[44] | Fedeli C, Torriani G, Galan-Navarro C, et al. Axl can serve as entry factor for lassa virus depending on the functional glycosylation of dystroglycan[J]. J Virol, 2018,92(5). |
[45] |
Chen J, Yang YF, Yang Y, et al. AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling[J]. Nat Microbiol, 2018,3(3):302-309.
doi: 10.1038/s41564-017-0092-4 URL |
[46] |
Brindley MA, Hunt CL, Kondratowicz AS, et al. Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein[J]. Virology, 2011,415(2):83-94.
doi: 10.1016/j.virol.2011.04.002 pmid: 21529875 |
[47] |
Meertens L, Carnec X, Lecoin MP, et al. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry[J]. Cell Host Microbe, 2012,12(4):544-557.
doi: 10.1016/j.chom.2012.08.009 pmid: 23084921 |
[48] | Wang ZY, Wang PG, An J. The multifaceted roles of TAM receptors during Viral Infection[J]. Virol Sin, 2020:457-468. |
[49] |
Wynn TA. Cellular and molecular mechanisms of fibrosis[J]. J Pathol. 2008,214(2):199-210.
pmid: 18161745 |
[50] |
Allinovi M, De Chiara L, Angelotti ML, et al. Anti-fibrotic treatments: A review of clinical evidence[J]. Matrix Biol, 2018, 68-69:333-354.
doi: S0945-053X(17)30431-6 pmid: 29654884 |
[51] | Bellan M, Cittone MG, Tonello S, et al. Gas6/TAM system: A key modulator of the interplay between inflammation and fibrosis[J]. Int J Mol Sci, 2019,20(20). |
[52] |
Espindola MS, Habiel DM, Narayanan R, et al. Targeting of TAM receptors ameliorates fibrotic mechanisms in idiopathic pulmonary fibrosis[J]. Am J Respir Crit Care Med, 2018,197(11):1443-1456.
doi: 10.1164/rccm.201707-1519OC URL |
[53] |
Bárcena C, Stefanovic M, Tutusaus A, et al. Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation[J]. J Hepatol, 2015,63(3):670-678.
doi: 10.1016/j.jhep.2015.04.013 URL |
[1] | HUA Xiu-feng;WANG Yan-wei;Cong Jin;LIU Fu-jun;MENG Xiao-mei;LI Hua-feng;JIN Shao-hua;WANG Hai-yan;LI Jian-yuan;SUN Qiang. Pancreatic islets differentiated from human embryonic stem cells correct hyperglycemia in non-obese diabetic /severe combined immunodeficient mice [J]. CLINICAL FOCUS, 2013, 28(6): 650-0. |
[2] | SHEN Jian-gang;AN Jun-yan;SANG Rong-xia;WEI Juan;HUO Xiao-xia;ZHANG Xiao-lan. Role of membrane-type matrix metalloproteinase-1 in apoptosis of hepatic stellate cell induced by focal adhesion kinase-related non-kinase in vitro [J]. CLINICAL FOCUS, 2009, 24(15): 1309-1312. |
[3] | . [J]. CLINICAL FOCUS, 2008, 23(16): 1188-1189. |
[4] | . [J]. CLINICAL FOCUS, 2002, 17(9): 553-554. |
[5] | . [J]. CLINICAL FOCUS, 2002, 17(3): 171-172. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||