Abstract:

Objective To investigate the correlation between atherogenic index of plasma (AIP) and nonalcoholic fatty liver disease (NAFLD). Methods Totally 160 patients who admitted to Health Checkup Center, Wangjiang Hospital, Sichuan University from May 2020 to May 2021 were enrolled, those patients underwent color doppler ultrasound and were initially diagnosed as NAFLD without drug therapy (NAFLD group), meanwhile, selected concurrent 160 age- and sex- matched controls (control group). The recorded data included age, height, weight, blood pressure, body mass index (BMI); blood lipid tests were performed in groups to calculate the AIP. The difference indicators of two groups were compared, NAFLD-related factors were performed in Logistic regression analysis, receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of AIP for NAFLD. Results Except for stature, differences in the other indicators of two groups were statistically significant. The risk factors for NAFLD were AIP (OR=2.070, 95%CI: 1.785-2.732, P<0.01) and BMI (OR=1.46, 95%CI: 1.172-1.819, P<0.01). The ROC curve of diagnostic index of AIP for NAFLD showed that the areas under curve (AUC), cut-off value, sensitivity and specificity were 0.899(Z=13.233, P<0.01), 1.896(95%CI: 0.836-1.943), 82.93% and 88.10%, respectively. Conclusion Strong correlation were found between AIP and NAFLD, AIP can take on the role of screening indicator for the risk of NAFLD.

Key words: nonalcoholic fatty liver disease, blood lipid, atherogenic index of plasma