Clinical characteristics of children with Mycoplasma pneumoniae infection complicated with asthmatic bronchopneumonia

doi:10.3969/j.issn.1004-583X.2024.09.007

Abstract

Abstract:

Objective To investigate the clinical characteristics of children with Mycoplasma pneumoniae (MP) infection complicated with asthmatic bronchopneumonia. Methods Fifty children with MP infection and asthmatic bronchopneumonia admitted to Children's Hospital Affiliated to Zhengzhou University from September 2021 to February 2023 were selected as the observation group, and 50 children with MP infection but not asthmatic bronchopneumonia during the same period were selected as the control group. The levels of T cell lymphocyte subsets (CD₃⁺, CD₄⁺, CD₈⁺), immunoglobulins (IgG, IgM and IgE), and lung function (vital capacity [VC], forced expiratory volume in the first second [FEV₁], forced vital capacity [FVC], peak expiratory flow [PEF], maximum mid-expiratory flow [MMEF]), serum inflammatory factors (transforming growth factor-beta1 [TGF-β1], tumor necrosis factor alpha [TNF-α]), and complement C3 levels were compared. Results The levels of CD₃⁺, CD₄⁺, CD₈⁺ in the observation group were significantly higher than those of control group (p<0.05). IgG, IgM, and IgE levels in the observation group were significantly higher than the control group (P<0.05). The levels of VC, FEV₁, FVC, PEF and MMEF in the observation group were significantly lower than those of control group (P<0.05). The levels of TNF-α and complement C3 in the observation group were significantly higher than those of control group (P<0.05). There was no significant difference in TGF-β1 level between the two groups (P>0.05). Conclusion Children with MP infection and asthmatic bronchopneumonia have a significant immune response, reduced pulmonary function, and increased levels of TNF-α and complement C3.

Key words: pneumonia, Mycoplasma, asthmatic bronchopneumonia, child, T cell lymphocyte subsets, transforming growth factor-β1, complement C3

CLC Number:

R563.1

Yang Xiaolin, Yang Yan. Clinical characteristics of children with Mycoplasma pneumoniae infection complicated with asthmatic bronchopneumonia[J]. Clinical Focus, 2024, 39(9): 808-811.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.09.007

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I9/808

Figures/Tables 5

Tab.1 General data between the two groups

组别	例数	性别[例(%)]		年龄(岁)	体重(kg)	身高(cm)
组别	例数	男	女	年龄(岁)	体重(kg)	身高(cm)
观察组	50	26(52.00)	24(48.00)	8.12±3.51	15.68±5.04	136.03±35.27
对照组	50	28(56.00)	22(44.00)	8.28±3.64	16.19±5.97	135.66±34.84
$t$ /χ²值		1.161		-0.224	-0.462	0.053
P值		0.688		0.823	0.645	0.958

Tab.1 General data between the two groups

组别	例数	性别[例(%)]		年龄(岁)	体重(kg)	身高(cm)
组别	例数	男	女	年龄(岁)	体重(kg)	身高(cm)
观察组	50	26(52.00)	24(48.00)	8.12±3.51	15.68±5.04	136.03±35.27
对照组	50	28(56.00)	22(44.00)	8.28±3.64	16.19±5.97	135.66±34.84
$t$ /χ²值		1.161		-0.224	-0.462	0.053
P值		0.688		0.823	0.645	0.958

Tab.2 T cell subsets between the two groups

组别	例数	C $D 3 +$ (%)	C $D 4 +$ (%)	C $D 8 +$ (%)
观察组	50	75.81±12.46	39.55±8.54	29.74±6.38
对照组	50	62.57±9.23	34.28±7.17	25.47±4.36
$t$ 值		6.038	3.342	3.907
P值		0.000	0.001	0.000

Tab.2 T cell subsets between the two groups

组别	例数	C $D 3 +$ (%)	C $D 4 +$ (%)	C $D 8 +$ (%)
观察组	50	75.81±12.46	39.55±8.54	29.74±6.38
对照组	50	62.57±9.23	34.28±7.17	25.47±4.36
$t$ 值		6.038	3.342	3.907
P值		0.000	0.001	0.000

Tab.3 Immunoglobulin levels between the two groups

组别	例数	IgG(g/L)	IgM(g/L)	IgE(g/L)
观察组	50	12.54±3.47	1.82±0.54	127.34±15.08
对照组	50	10.45±4.01	1.63±0.39	106.46±13.34
$t$ 值		2.787	2.017	7.333
P值		0.006	0.046	0.000

Tab.3 Immunoglobulin levels between the two groups

组别	例数	IgG(g/L)	IgM(g/L)	IgE(g/L)
观察组	50	12.54±3.47	1.82±0.54	127.34±15.08
对照组	50	10.45±4.01	1.63±0.39	106.46±13.34
$t$ 值		2.787	2.017	7.333
P值		0.006	0.046	0.000

Tab.4 Pulmonary function between the two groups

组别	例数	VC(ml)	FEV₁(%)	FVC(%)	PEF(%)	MMEF(%)
观察组	50	63.58±7.49	44.36±10.58	63.32±7.96	53.61±8.21	44.65±8.62
对照组	50	82.71±13.58	64.29±14.06	81.94±15.83	72.54±10.37	73.12±15.43
$t$ 值		-8.722	-8.009	-2.830	-10.120	-11.390
P值		0.000	0.000	0.006	0.000	0.000

Tab.4 Pulmonary function between the two groups

组别	例数	VC(ml)	FEV₁(%)	FVC(%)	PEF(%)	MMEF(%)
观察组	50	63.58±7.49	44.36±10.58	63.32±7.96	53.61±8.21	44.65±8.62
对照组	50	82.71±13.58	64.29±14.06	81.94±15.83	72.54±10.37	73.12±15.43
$t$ 值		-8.722	-8.009	-2.830	-10.120	-11.390
P值		0.000	0.000	0.006	0.000	0.000

Tab.5 Levels of serum inflammatory factors and complement C3 between the two groups

组别	例数	TGF-β1 (pg/ml)	TNF-α (pg/ml)	补体C3 (g/L)
观察组	50	31.67±4.78	4.65±1.69	1.97±0.58
对照组	50	32.24±4.36	4.08±1.08	1.71±0.54
$t$ 值		-0.623	2.010	2.320
P值		0.535	0.047	0.022

Tab.5 Levels of serum inflammatory factors and complement C3 between the two groups

组别	例数	TGF-β1 (pg/ml)	TNF-α (pg/ml)	补体C3 (g/L)
观察组	50	31.67±4.78	4.65±1.69	1.97±0.58
对照组	50	32.24±4.36	4.08±1.08	1.71±0.54
$t$ 值		-0.623	2.010	2.320
P值		0.535	0.047	0.022

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