Clinical significance of neuron-specific enolase and brain active peptide protein in patients with acute carbon monoxide poisoning

doi:10.3969/j.issn.1004-583X.2016.01.018

Abstract

Abstract: Objective To investigate the clinical significance of neuron-specific enolase (NSE) and brain active peptide 100-β (S-100 β) protein in patients with acute carbon monoxide poisoning (ACOP).Methods All patients with ACOP was divided into mild, moderate and severe groups according to Glasgow Coma Scale (GCS) score. Healthy cases were selected as control group. The NSE and S-100β protein levels were measured by chemiluminescence immune assay.Results Compared with the control group, the levels of NSE and S-100β in patients with ACOP were significantly higher (P<0.01). The levels of NSE and S-100β were significantly higher in moderate and severe groups than in mild group (P<0.01). The levels of NSE and S-100β in dead patients were significantly higher, however, the number of cases was limited to be excluded from the statistical analysis.Conclusion The levels of NSE and S-100β could reflect the degree of brain injury in patients with ACOP and has great significance in treatment and prognosis.

Key words: carbon monoxide poisoning, phosphopyruvate hydratase, s100 proteins

CLC Number:

R827.176

Jin Pingyan, Lin Ming. Clinical significance of neuron-specific enolase and brain active peptide protein in patients with acute carbon monoxide poisoning[J]. Clinical Focus, 2016, 31(1): 71-73.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.01.018

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I1/71

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