Abstract: Objective To study the effect of the combination therapy of diabetes information management system (DIMS) and diabetes patient peer education on self-management level and comprehensive index in patients with type 2 diabetes mellitus(T2DM).Methods A total of 200 out-patients with T2DM were chosen and randomly divided into three groups: group A with combination treatment of making e-medical records using DIMS and patient peer education, group B with combination treatment of DIMS and traditional health education,group C with common diabetes treatment. The levels of FPG, 2 hPG, HbA₁c, BP, TC, TG, HDL-C, LDL-C and BMI were recorded before and after 12 months’ treatment.All the patients’ knowledge of diabetes and self-management behavior before and after 12 months’ treatment were evaluated.Results After 12 months’ treatment, the goal attainment rates of FPG, 2 hPG, HbA₁c, HDL-C, LDL-C, TG, TC, BMI and BP were significantly improved in group A and B(P＜0.05),the goal attainment rate of BP was significantly improved in group C(P<0.05).After 12 months’ treatment, the goal attainment rates of FPG, 2 hPG, HbA₁c, HDL-C, LDL-C, TG, TC and BMI were significantly increased in group A than in group C(P＜0.05), the goal attainment rates of 2 hPG, HbA₁c, HDL-C, LDL-C, TG, TC and BMI were significantly increased in group A than in group B(P＜0.05).After 12 months’ treatment, the knowledge of diabetes and self-management behavior were significantly improved in group A than in group B and C(P＜0.05).Conclusion Combination model of DIMS and patient peer education management can improve the self-management level of T2DM and the metabolic parameters.