Abstract: ObjectiveTo explore the clinical significance of  highlysensitivity Creactive protein (hsCRP) and immune function in children with handfoot  and  mouth disease (HFMD). MethodsA total of 60 children with severe HFMD were selected as research group， and as control group， 100 cases of healthy children were enrolled. Using the immune turbidimetry， hsCRP， immunoglobulin (IgA， IgG， IgM， C3 and C4) and T lymphocyte subsets (CD3+， CD4+ and CD8+) were detected.  ResultshsCRP and WBC in acute phase and recovery phase in research group were significantly higher than those in control group (P<0.01). hsCRP and WBC in recovery phase were significantly lower than those in acute phase， however，and they were significantly higher than those in control group (P<0.01). IgA  in acute phase and recovery phase in observation group was significantly lower than that in control group (P<0.05). IgG， C3 and C4 in acute phase and recovery phase in observation group were significantly higher than those in control group (P<0.05).  CD3+， CD4+ and CD4+/CD8+  ratio in acute phase and recovery phase in observation group were significantly lower than those in control group (P<0.05). CD3+ in recovery phase was significantly higher than that in the acute phase of observation group (P<0.05). ConclusionInflammation and myocardial injury can be detected in children with HFMD by hsCRP monitor， obviously lower function in cellular immunity and humoral immunity can be observed in acute phase of severe children with HFMD and in the recovery phase， the humoral immunity， cellular immunity and inflammation become gradually normal.

Key words: hand, foot and mouth disease；immunomodulation；creactive protein