Abstract: Objective  To investigate  the relationship between functional dyspepsia（FD）  and mental psychological factors and explore the clinical significance of brain function check diagnosis on FD patients associated with anxiety and depression state. Methods  Psychological assessments， SelfRating Anxiety Scale(SAS) and SelfRating Depression Scale(SDS) were performed on 100 FD patients and 30 healthy volunteers. Electroencephalogram(EEG) and encephalofluctuo gram technology(ET) were also performed to compare  the abnormal rates and the differences of neurotransmitter between FD and control group. Results  Of 100 FD patients， the incidence rates of anxiety， depression and both anxiety and depression states were  30%， 33% and 11%， respectively.Of 30 healthy volunteers， the incidence rates of anxiety and depression were  6.7% and 10%， respectively. The scores of  SDS  and SAS  in  FD group were obviously higher than those of control group（P＜0.05）.EEG abnormal rate in  FD patient group was significantly  higher than that of control group， respectively  35% and 10%（P＜0.05).Neurotransmitters γaminobutyric acid(GABA) activity was decreased much more in FD with anxiety state than that of control group，while norepinephrine(NE)， acetylcholine(Ach) and glutamic acid(Glu)  activities were significantly  higher than those of control group (P<0.05). Neurotransmitters 5hydroxytryptamine(5HT) and dopamine(DA) were  much lower in FD patients with depression state than those of the control group (P<0.05). 5HT and DA were  lower in FD with anxiety and depression state than those of control group， but NE was significantly  higher than that of control group (P<0.05). There  was  no statistical significance in the difference of neurotransmitter activity between FD patients without anxiety and depression state and control group (P>0.05).Conclusion  The incidence rate of anxiety and depression state and the abnormity of EEG in FD patients are much higher than common people， the reason is due to the inordinate changes of neurotransmitter in the brain.

Key words: dyspepsia, anxiety；depression, neurotransmitter