Abstract: Objective  To evaluate therapeutic effect of emodin loaded solid lipid nanoparticles (EMOSLN) on  Parkinson model of  rats. Methods  EMOSLN were prepared by applying emulsion evaporationsolidification at low temperature method with glyceryl monostearate and cremophor RH40 as well as polysorbate 80(tween 80) (3:1，w/w). To observe the influence of EMOSLN in 6OHDA induced  the behavior  of  Parkinson model rats′， concentration of MAOB and COMT in middle brain following oral administration， therapeutic effect of EMOSLN on rats model of Parkinson disease.Results  EMOSLN was spherical in morphology and the diameter was in the range of 40100 nm. Compared with Parkinson disease model rats divided into normal saline group， rotating behavior of rats in EMOSLN group and emodin suspension group was improved. Concentrations of MAOB and COMT in middle brain of Parkinson disease model rats for EMOSLN group were significantly reduced，while MAOB concentration in middle brain of emodin suspension group reduced significantly but COMT concentration showed no significant difference compared to normal saline control group. Conclusion  EMOSLN showed effect on 6OHDA rat model of Parkinson disease by lowering concnentation of COMT and MAOB， and its therapeutic efficiency is better than that of emodin suspension.

Key words: Parkinsonian disorders； emodin, solid lipid nanoparticles