Abstract: Objective  To observe the clinical manifestation and the therapeutic efficacy of intravenous immunoglobulin(IVIg) for patients with GuillainBarré syndrome following trauma and operation. Methods  A retrospective analysis was conducted on 16 patients with GuillainBarré syndrome following trauma and operation. Then, these patients were compared with nontrauma and nonoperation patients in aspect of clinical features and IVIg therapeutic efficacy. Results  The patients complicated with GuillainBarré syndrome within 3 weeks after trauma and operation may have pharyngalgia and diarrhea before GuillainBarré syndrome. The major clinical manifestations were weakness and numbness of limbs and some severe cases had symptom of dyspnea. The physical signs were low muscular tension and deep tendon reflex or disappeared with or without paresthesia. The clinical pictures of the patients were more severe than nontraumatic and nonoperatic cases. In CSF of most patients, dissociation of protein from cell can be found. The electromyography examination showed demyelization and axonal degeneration. After IVIg  therapy,  the efficacy of  patients following trauma and operation was poor as compared with that of  nontrauma and nonoperation patients(P＜0.01). Conclusion  The efficacy of  IVIg  in patients following  trauma and operation is poor.  Doctors should treat secondary GuillainBarré syndrome patients after trauma and operation to improve the prognosis of patients through intime diagnosis and treatment.

Key words: Guillain-Barré   , syndrome；trauma；immunoglobulins