Abstract: Objective  Pregnants of systemic lupus erythematosus(SLE) with antiphospholipid syndrome(APS) may present morbid pregnancies,  this study aimed for the mild  and moderate activity patients with small doses of immunoglobulin G (IVIG) preventive treatment to observe the prognosis of patients and their fetus. Methods  Sixty cases of SLE pregnant women were randomly divided into  control group and  observation group. The observation group received gamma globulin 10 g  once a month in addition to regular treatment until the production; observation was performed in pregnancy outcome,  patients’ condition,  fetal physical condition. Results  There was no difference in general information  except the complement (C3) at enrolling. The incidence of pregnancyinduced hypertension and fetal distress was lower in observation group than in  control group (P<0.05). But the incidence of eclampsia,  premature rupture of membranes,  and oligohydramnios C3,  antidsDNA antibody positive cases,  antiβ2  GPI positive cases,  ACAIgA/IgM，bleeding,  abortion,  premature delivery,  intrauterine fetal malformations， in the incidence of atrioventricular block,  rash,  low birth weight,  and Apgar scores 47 points in newborns,  the occurrence of intrauterine infection,  poor healing of cesarean section wounds,  changes in hormone immunosuppressive drug use,  and incidence of new infantile diseases and deaths showed no  significant difference between  two groups (P>0.05). However,  in observation group,  the proportion of pregnant women who chose to deliver was higher than that of  control group. The SLEDAI score of observation group during pregnancy was lower than that of control group.  The breastfeeding rate was higher in  observation group than in control group (P<0.05). Conclusion  Lowdose gamma globulin can improve the success rate of pregnancy and reduce pregnancy complications and postpartum complications in patients with SLE and APS.

Key words: lupus erythematosus, systemic;pregnancy;antiphospholipid syndrome, gammaglobulins