Abstract: Objective  To observe the clinical value of serum claudin1 (Cla1), midkine (MK), and galectin1 (Gal1) levels in the diagnosis of Hashimoto thyroiditis (HT) with papillary thyroid cancer (PTC). Methods  Totally 107 HT patients with PTC in our hospital from January 2018 to December 2019 were selected as HT  with  PTC group, meanwhile, 65 HT patients and 30 healthy people examined in our hospital during the same period were selected as the HT group and the healthy control group, respectively. The serum Cla1, MK and Gal1  levels were observed in each group. And the correlation among serum Cla1, MK and Gal1 levels in HT patients with PTC, HT stage, and TNM stage were also observed, as well as its diagnostic value for  HT with PTC.Results  The serum Cla1, MK and Gal1 levels in HT with PTC group were significantly higher than those in HT group and healthy control group (P<0.01). The serum Gal1 level in HT group was obviously higher than that in health control group (P<0.01). The levels of serum  Cla1, MK and Gal1 in HT patients with PTC increased significantly with the increase of HT stage and TNM stage (P<0.01). The serum Cla1 level was positively correlated with MK and Gal1 levels in HT patients with PTC, and the serum MK was positively correlated with Gal1. The serum Cla1, MK and Gal1  levels had higher sensitivity and specificity in the diagnosis of HT with PTC. The sensitivity and specificity of the combined detection were  88.8% and 90.8%, respectively. And the AUC was 0.941, which was significantly higher than that measured by the detection of Cla1, MK and Gal1, respectively. Conclusion  The Cla1, MK and Gal1 are involved in the development of HT with PTC, which havehigher diagnostic efficacy in predicting the occurrence of  PTC  in HT patients.

Key words: thyroid neoplasms, claudins, hemagglutinins