Abstract:

Objective To explore the epidemiological characteristics of adenovirus respiratory tract infection in hospitalized children in southern Hebei Province. Methods The adenovirus respiratory tract infection children who were admitted to the Children's Hospital of Hebei Province (March 2017 to February 2021) were retrospectively analyzed. Results There were adenovirus respiratory tract infection 2, 356 of the 32, 682 hospitalized children with acute respiratory tract infection, with a detection rate of 7.2%. The viral positive rate was 12.4% in the group of 1-3 years old. The infection type was mainly bronchopneumonia (47.3%). The rate of severe pneumonia was 12.4%. Among children aged from 1 month to <1 year, the proportion of severe pneumonia was the highest, and the proportion of severe pneumonia in winter is the highest(all P<0.05). The classified 311 adenovirus strains contained three types: human adenovirus type 2 (Ad2)(n=54, 17.4%), Ad3 (n=146, 46.9%), Ad7 (n=111, 35.7%). The detection rate of Ad7 in severe pneumonia and death cases was the highest (all P<0.05). Conclusion In the comparison to national level, the acute respiratory tract infection children in southern Hebei Province have slightly higher detection rate of adenovirus respiratory tract infection detection and incidence of severe pneumonia. Children with aged 1 month to less than 1 year before, or incidence in winter, or Ad7 infection, or other pathogens co-infection are prone to severe pneumonia.

Key words: adenoviruses, human, respiratory tract infections, child, epidemiology