Correlation between serum Vitamin B12 and mild cognitive impairment in elderly patients with type 2 diabetes mellitus

doi:10.3969/j.issn.1004-583X.2024.01.005

Abstract

Abstract:

Objective To investigate the correlation between serum vitamin B₁₂ (VB₁₂) level and mild cognitive impairment (MCI) in elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 120 elderly T2DM patients admitted to the Endocrinology Department of Fushun Central Hospital from January 2023 to July 2023 were collected. According to the tertiles of the measured serum VB₁₂, patients were divided into A group (200 ng/L≤VB₁₂<500 ng/L, $n$ =36), B group (500 ng/L≤VB₁₂<800 ng/L, $n$ =71), and C group (800 ng/L≤VB₁₂<1100 ng/L, $n$ =13). The cognitive function of patients was evaluated using the Simple Montreal Cognitive Assessment (MoCA) scale. The prevalence of MCI was compared among the three groups. Logistic regression was performed to analyze the relative risks for MCI in elderly T2DM patients with different levels of vitamin B₁₂. Results The incidence of MCI decreased with the increasing serum VB₁₂ level. After adjusting for gender, age, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), logistic regression results showed that with Group C as the reference group, the odds ratio ( $O R$ ) and corresponding 95% confidence interval ( $C I$ ) for MCI in Group A was 6.121 and 1.161-32.265, respectively. Conclusion Serum VB₁₂ ranging from 200 ng/L to 500 ng/L is an independent risk factor for MCI in elderly T2DM patients.

Key words: diabetes mellitus, type 2, vitamin B₁₂, mild cognitive impairment

CLC Number:

R587.1

Zhang Jianan, Sun Linlin, Zhan Xiaoyan, Li Bing. Correlation between serum Vitamin B₁₂ and mild cognitive impairment in elderly patients with type 2 diabetes mellitus[J]. Clinical Focus, 2024, 39(1): 34-37.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.01.005

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I1/34

Figures/Tables 3

Tab.1 Comparison of clinical data among three groups

项目	A组( $n$ =36)	B组( $n$ =71)	C组( $n$ =13)	$F$ / $H$ /χ²值	$P$ 值
年龄(岁)	71.5(68, 75.75)	70(67, 73)	68(67, 71)	6.773	0.034
男/女(例)	22/14	30/41	6/7	3.429	0.180
BMI(kg/m²)	24.64±2.81	24.23±3.18	25.46±3.92	0.894	0.412
收缩压(mmHg)	150.47±21.61	150.69±18.71	148.46±23.49	0.140	0.869
舒张压(mmHg)	87.06±13.60	84.17±10.10	85.77±10.18	0.418	0.660
吸烟史[例(%)]	19.4	22.5	23.1	3.970	0.137
饮酒史[例(%)]	22.2	21.1	7.7	1.881	0.390
糖尿病病程(年)	10(1.25, 19.25)	10(5, 20)	10(4, 17)	1.167	0.558
受教育年限(年)	8.39±2.91	8.55±2.735	9.69±2.43	1.131	0.326
FPG(mmol/L)	10.40±3.17	10.70±3.29	9.81±2.25	0.468	0.628
TC(mmol/L)	5.91±1.36	5.25±1.37	5.11±1.60	3.373	0.038
TG(mmol/L)	2.36(1.56, 3.19)	1.80(1.34, 2.75)	1.51(1.27, 3.32)	0.250	0.882
HDL-C(mmol/L)	1.00±0.21	1.03±0.24	1.22±0.39	4.154	0.018
LDL-C(mmol/L)	3.87±0.80	3.18±0.91	2.86±1.18	9.274	0.001
FINS(mIU/L)	11.64(8.32, 16.19)	11.28(8.21, 19.76)	11.61(8.88, 22.21)	0.180	0.914
FC-P(ng/ml)	2.05(1.49, 2.80)	2.18(1.65, 3.00)	2.41(1.19, 3.59)	1.052	0.591
HbA₁c(%)	9.40±1.82	9.46±2.08	10.21±1.36	0.920	0.401
MoCA(分)	23.11±2.84	24.92±1.74	26.85±1.99	17.000	0.001

Tab.1 Comparison of clinical data among three groups

项目	A组( $n$ =36)	B组( $n$ =71)	C组( $n$ =13)	$F$ / $H$ /χ²值	$P$ 值
年龄(岁)	71.5(68, 75.75)	70(67, 73)	68(67, 71)	6.773	0.034
男/女(例)	22/14	30/41	6/7	3.429	0.180
BMI(kg/m²)	24.64±2.81	24.23±3.18	25.46±3.92	0.894	0.412
收缩压(mmHg)	150.47±21.61	150.69±18.71	148.46±23.49	0.140	0.869
舒张压(mmHg)	87.06±13.60	84.17±10.10	85.77±10.18	0.418	0.660
吸烟史[例(%)]	19.4	22.5	23.1	3.970	0.137
饮酒史[例(%)]	22.2	21.1	7.7	1.881	0.390
糖尿病病程(年)	10(1.25, 19.25)	10(5, 20)	10(4, 17)	1.167	0.558
受教育年限(年)	8.39±2.91	8.55±2.735	9.69±2.43	1.131	0.326
FPG(mmol/L)	10.40±3.17	10.70±3.29	9.81±2.25	0.468	0.628
TC(mmol/L)	5.91±1.36	5.25±1.37	5.11±1.60	3.373	0.038
TG(mmol/L)	2.36(1.56, 3.19)	1.80(1.34, 2.75)	1.51(1.27, 3.32)	0.250	0.882
HDL-C(mmol/L)	1.00±0.21	1.03±0.24	1.22±0.39	4.154	0.018
LDL-C(mmol/L)	3.87±0.80	3.18±0.91	2.86±1.18	9.274	0.001
FINS(mIU/L)	11.64(8.32, 16.19)	11.28(8.21, 19.76)	11.61(8.88, 22.21)	0.180	0.914
FC-P(ng/ml)	2.05(1.49, 2.80)	2.18(1.65, 3.00)	2.41(1.19, 3.59)	1.052	0.591
HbA₁c(%)	9.40±1.82	9.46±2.08	10.21±1.36	0.920	0.401
MoCA(分)	23.11±2.84	24.92±1.74	26.85±1.99	17.000	0.001

Fig.1 Comparison of prevalence of MCI among three groups

Tab.2 Effects of different levels of VB12 on MCI

模型	组别	$O R$ (95% $C I$ )	$P$ 值
1	A	8.667(1.969~38.151)	0.004
	B	4.301(1.090~16.974)	0.037
	C	1	-
2	A	7.657(1.687~34.766)	0.008
	B	4.100(1.031~16.295)	0.045
	C	1	-
3	A	6.121(1.161~32.265)	0.033
	B	3.643(0.855~15.523)	0.081
	C	1	-

Tab.2 Effects of different levels of VB12 on MCI

模型	组别	$O R$ (95% $C I$ )	$P$ 值
1	A	8.667(1.969~38.151)	0.004
	B	4.301(1.090~16.974)	0.037
	C	1	-
2	A	7.657(1.687~34.766)	0.008
	B	4.100(1.031~16.295)	0.045
	C	1	-
3	A	6.121(1.161~32.265)	0.033
	B	3.643(0.855~15.523)	0.081
	C	1	-

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Correlation between serum Vitamin B₁₂ and mild cognitive impairment in elderly patients with type 2 diabetes mellitus

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