Expression and clinical significance of apolipoprotein M in inflammatory bowel disease

doi:10.3969/j.issn.1004-583X.2016.01.013

Abstract

Abstract: Objective To investigate the expression and clinical value of serum apolipoprotein M (apoM) in patients with inflammatory bowel disease (IBD).Methods The levels of serum apoM and TNF-α in 101 IBD patients and 69 healthy individuals were measured by ELISA.Results The serum concentration of apoM was respectively (13.5±8.8) mg/L, (10.2±5.8) mg/L and (2.0±1.3) mg/L in ulcerative colitis (UC) patients, Crohn disease (CD) patients and healthy controls, and the level of serum apoM in UC patients was significantly higher than that of CD patients (P<0.05). Serum apoM concentrations in both UC and CD patients were significantly elevated with increased disease activity(P<0.05). In addition, serum apoM concentration and TNF-α concentration were positively correlated in IBD group (r=0.314,P=0.001), especially in CD subgroup (r=0.365,P=0.010).Conclusion The levels of serum apoM in UC and CD patients were correlated with disease activity and have potential application value in evaluating disease activity of IBD.

Key words: inflammatory bowel diseases, apolipoprotein M, disease activity

CLC Number:

R574

Wang Tingting, Wang Liangzhi. Expression and clinical significance of apolipoprotein M in inflammatory bowel disease[J]. Clinical Focus, 2016, 31(1): 53-55.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.01.013

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I1/53

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