Abstract:

Sjogren syndrome(SS) is a set of heterogeneous systemic autoimmune diseases characterized by dry mouth and dry eyes. There is often systemic involvement(extraglandular  manifestications). A variety of topical and systemic drugs are available to treat SS， although no evidencebased therapeutic guidelines are available. The therapeutic management of pSS is based on symptomatic treatment of glandular manifestations and on the use of diseasemodifying drugs for systemic involvement. Because mounting evidence points to a central pathophysiologic role for B cells， Bcell depletion is being evaluated as a treatment of SS. This review focuses on the major therapeutic discoveries of the last few years to offer practical methods for the treatment of patients with SS.

Key words: sjogren's syndrome, autoantibody, immunosuppressant, replacement therapy