Abstract: ObjectiveTo evaluate the indications， safety and efficiency of  elastic band ligation on upper gastrointestinal submucosal tumor(SMT) guided by endoscopic ultrasonography (EUS). MethodsThe study enrolled 69 patients with a total of 71 lesions， which were diagnosed as upper gastrointestinal SMT by EUS. The endoscopic elastic band ligation was performed on each of the patients. Then， all patients received proton pump inhibitor  treatment for two weeks and they were followed up with endoscopy after 24 weeks. ResultsOf  69 patients， the diameters of lesions ranged 0.51.5 cm, 32 cases(45.1%) located in esophagus， 23 cases(32.4%) in stomach， 16 cases(22.5%) in duodenal; 28 cases(39.4%) in deep mucosal， 20 cases(28.2%) in submucosal， 23 cases(32.4%) in muscularis propria， 56 cases(78.9%) with wide base， 15 cases(21.1%) with rebagliati， respectively; 63 cases(88.7%)  of them were sloughed successfully. Statistics showed that the decisive factors for successful treatment were the size， layer of invasion and elasticity. All patients had no bleeding， perforation， severe  guidance  dysphagia or other complications. ConclusionEUS is important for endoscopic elastic band ligation of upper gastrointestinal SMT. The tumor size， layer of invasion and elasticity can be evaluated by EUS precisely.

Key words: gastrointestinal neoplasms;endosonography, ligation