Abstract: ObjectiveTo analyze the neuropsychiatric symptoms of the patients poisoned with compound paracetamol and amantadine hydrochloride capsules. MethodsThe clinical data of ten patients poisoned with compound paracetamol and amantadine hydrochloride capsules were retrospectively analyzed. ResultsThe mean age of onset in ten patients was (73.8±9.0) years old， four cases of them had a history of uremia. The main symptoms included dyskinesia and psychiatric symptoms. Dyskinesia mainly presented  with postural tremor (100%) and unsteady walking (10.0%). Psychiatric symptoms mainly presented with insomnia (50.0%)， hallucinations (60.0%)， euphoric spirit (10.0%) and slow response (20.0%). The concomitant symptoms included vague words， headache， palpitations and sweating. Major misdiagnosed diseases included intracranial infection， uremic encephalopathy，cerebral infarction and low blood sugar. Most of the patients recovered after drug withdrawal and fluid replacement， a minority of them recovered after the blood perfusion combined with hemodialysis. ConclusionThe patients poisoned with compound paracetamol and amantadine hydrochloride capsules mainly presented with dyskinesia and psychiatric symptoms， who were prone to be found in the elderly and the patients with renal insufficiency.

Key words: drug toxicity；dyskinesia, druginduced； psychiatric symptoms, compound paracetamol and amantadine hydrochloride capsules