Abstract: ObjectiveTo observe the effect of ultrasound combined with electrical stimulation guided injection of botulinum toxin type A（BTXA）for the treatment of spasticity in early cerebral vascular accident patients. MethodsFortysix early cerebral vascular accident patients with lower limb spasticity were divided randomly into two groups: treatment  group（23 patients）  and control group(23 patients).Patients in control group got routine rehabilitation training， and those in treatment group were given ultrasound combined with electrical stimulation guided injection of botulinum toxin type A additionally. The functions of two groups were evaluated by using the modified Ashworth scale(MAS)，FuglMeyer assessment（FMA），intergrated electromyography（iEMG），WHO Quality of LifeBREF（WHOQOLBREF）  before and six weeks after treatment. ResultsAfter six weeks of treatment， the treatment group improved much better than the control group. The average MAS，FMA，WHOQOLBREF，iEMG score in treatment group were significantly higher than those  of control group(P<0.05).ConclusionUltrasound combined with electrical stimulation guided injection of botulinum toxin type A for the treatment of spasticity in early cerebral vascular accident patients is effective， accurate and safe.

Key words: cerebral vascular accident, botulinum toxin type A, spasticity, ultrasound, electrical stimulation