Abstract: Objective  To analyze the clinical features and risk factors of cardiac rupture (CR) complications in patients with acute myocardial infarction (AMI)， and to identify the risk factors for early identification of cardiac rupture and to reduce the incidence of complications. Methods  The clinical data of 1 110 cases of AMI admitted to the hospital from September 2014 to November 2016 were reviewed， and 37  cases combined with CR assigned into study group， and 111 cases from 1∶3  pairmatched randomly in non CR AMI patients were control group. Clinical information was compared between two groups and the relevant risk factors for predicting CR were studied by logistic regression analysis. Results  The two groups showed statistical significances in the age of patients (72.92±7.84) years old vs (66.25±10.05) years old (P<0.05)， the proportion of women (51.35% vs 26.13%，P<0.05)， the treatment time 7 (5，48) h vs 5 (3，12) h(P<0.05)， heart rate (85.30±23.02) beats/min vs  (76.53±16.41) beats/min(P<0.05)， TG 0.99(0.86，1.36) mmol/L vs 1.35(1.00，1.95) mmol/L(P<0.05)， reperfusion ratio 5 cases (13.51%) vs 43 cases(38.74%)(P<0.05) and using angiotensinconverting enzyme inhibitor(ACEI) and beta blockers ratio 10 cases （27.03%） vs 52 cases（46.85%）(P<0.05). Logistic multifactor regression analysis suggested that the age and not using of ACEI and beta blockers were independent risk factors. The mean time of incidence of CR after AMI was (4.65±3.37) days， and 41.67% of AMI had abnormal incentives before the onset of CR. Conclusion  Advanced age， women， treatment time delay， high admission heart rate， low TG， without infusion therapy and not using of ACEI and beta blockers were high risks for CR. Advanced age and not using of ACEI and beta blockers were independent risk factors.Early reperfusion of infarct related artery completely， early using of ACEI and beta blockers， avoiding mood swings and ambulation could reduce the incidence of CR after AMI.

Key words: myocardial infarction, heart rupture, risk factors