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Role of  ubiquitinspecific proteases 46  gene in blood of patients with systemic lupus erythematosus

  

  1. 1.Department of Pathology， Hebei Medical University， Shijiazhuang 050017，China;
    2a.Department of Nosocomial Infection Control；2b.Department of Rheumatology，
    Hebei General Hospital， Shijiazhuang 050051，China; 3.Department of Rheumatology，
    the Second Hospital of Hebei Medical University， Shijiazhuang 050000，China
  • Online:2017-08-05 Published:2017-08-10
  • Contact: Corresponding author: Liu Shuxia，Email: susanliu1976@163.com

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Abstract: Objective  To investigate the role of  ubiquitinspecific proteases 46 (Usp46) in the blood of systemic lupus erythematosus (SLE) patients and healthy population. Methods  Real  time polymerase chain reaction analysis was used to determine the Usp46 expression in the blood of 73 patients with SLE and 75 healthy controls.Results  The mRNA expression level of Usp46 was significantly increased， about 4.22（1.30，17.02）  folds， in samples from SLE patients compared to healthy population (Z=-6.98，P＜0.01). In addition， there was significantly positive correlation between the expression level of Usp46 and ESR， IgG， IgM and ALT (P＜0.05). Conclusion  The mRNA expression level of Usp46 was significantly higher in SLE patients than in healthy population， which indicates that Usp46 may participate in the development of SLE process.

Key words: lupus erythematosus, systemic；genes；blood sedimentation；ubiquitin specific protease 46