Abstract: Objective  To evaluate the clinical efficacy and safety of noninvasive positive pressure ventilation(NPPV) for patients with mild or moderate acute respiratory distress syndrome（ARDS） induced by sepsis,  and to analyze the independent risk factors of NPPV treatment failure. Methods  A retrospective observation was conducted. NPPV  was used for mild or moderate ARDS patients induced by sepsis who admitted to Intensive Care Unit of Baoding First Hospital from January 2013 to December 2018. Fiftysix patients with ARDS treated with NPPV，according to whether patients needed invasive ventilation finally, were divided into success group and failure group. The data included general state,  Acute Physiology and Chronic Health Evalution Ⅱ (APACHEⅡ) score，ARDS cause,  NPPV related parameters,  vital signs and blood gas analysis before and after NPPV. Results  Of all the patients, 36 fell into the success group,  while 20 (35.7%)  were included failure group.  The multivariate analysis showed that higher APACHEⅡ  score（P=0.039），PaO2/ FiO2<145 mmHg after two hours of NPPV（P=0.000）,  RR>30 times/min after two hours of NPPV（P=0.016）, and pulmonary infection derived ARDS（P=0.026）  were the independent risk factors of NPPV treatment failure．Conclusion  NPPV might be an effective and safe method for treatment of patients with mild or moderate ARDS  induced by sepsis.  The independent risk factors associated with failure of NPPV were higher APACHEⅡ  score,  PaO2/FiO2 <145 mmHg after two hours of NPPV,  RR>30 times/min after two hours of NPPV,  and pulmonary infection derived ARDS.

Key words: ventilation, artificial；sepsis； respiratory distress syndrome；factor analysis, , statistical